Abstract
Stress has a negative impact on wound healing. This murine study evaluated the effect of restraint stress (RST) on interleukin-1 (IL-1) and keratinocyte growth factor-1 (KGF-1) gene expression in cutaneous wounds by in situ hybridization. At day 1, RST mice had reduced frequency of IL-1β mRNA-expressing fibroblasts compared to control mice. At day 3, RST mice had reduced frequencies of IL-1β mRNA-expressing leukocytes, KGF-1 mRNA-expressing fibroblasts, and thin proliferating zones of epithelium. At day 5, RST mice had persistent leukocytic foci and reduced granulation tissue. Therefore, stress-induced alterations in cutaneous proinflammatory cytokine and growth factor expression are associated with significant histological changes in healing wounds.
Original language | English (US) |
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Pages (from-to) | 74-83 |
Number of pages | 10 |
Journal | Journal of Neuroimmunology |
Volume | 129 |
Issue number | 1-2 |
DOIs | |
State | Published - 2002 |
Externally published | Yes |
Keywords
- IL-1
- In situ hybridization
- KGF-1
- Mice
- Stress
- Wound healing
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology