Restriction of placental vasculature in a non-human primate: A unique model to study placental plasticity

V. H.J. Roberts; J. P. Räsänen; M. J. Novy; A. Frias; S. Louey; T. K. Morgan; K. L. Thornburg; E. R. Spindel; P. L. Grigsby

doi:10.1016/j.placenta.2011.10.003

Restriction of placental vasculature in a non-human primate: A unique model to study placental plasticity

V. H.J. Roberts, J. P. Räsänen, M. J. Novy, A. Frias, S. Louey, T. K. Morgan, K. L. Thornburg, E. R. Spindel, P. L. Grigsby

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The limits of placental plasticity, i.e., the ability of the placenta to adapt and alter its growth trajectory in response to altered fetal requirements, are not known. We report fetal and placental hemodynamic adaptations in a novel non-human primate model in which the fetal inter-placental bridging vessels were surgically ligated. Doppler ultrasound studies showed that the rhesus placenta compensates for an approximate 40% reduction in functional capacity by increased growth and maintenance of umbilical volume blood flow. This unique experimental animal model has applications for mechanistic studies of placental plasticity and the impact on fetal development.

Original language	English (US)
Pages (from-to)	73-76
Number of pages	4
Journal	Placenta
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/j.placenta.2011.10.003
State	Published - Jan 2012

Keywords

Developmental programming
Fetal growth restriction
Feto-placental blood flow
Non-human primate
Placental plasticity

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology
Developmental Biology

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10.1016/j.placenta.2011.10.003

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abstract = "The limits of placental plasticity, i.e., the ability of the placenta to adapt and alter its growth trajectory in response to altered fetal requirements, are not known. We report fetal and placental hemodynamic adaptations in a novel non-human primate model in which the fetal inter-placental bridging vessels were surgically ligated. Doppler ultrasound studies showed that the rhesus placenta compensates for an approximate 40% reduction in functional capacity by increased growth and maintenance of umbilical volume blood flow. This unique experimental animal model has applications for mechanistic studies of placental plasticity and the impact on fetal development.",

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AU - Räsänen, J. P.

AU - Novy, M. J.

AU - Frias, A.

AU - Louey, S.

AU - Morgan, T. K.

AU - Thornburg, K. L.

AU - Spindel, E. R.

AU - Grigsby, P. L.

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Restriction of placental vasculature in a non-human primate: A unique model to study placental plasticity

Abstract

Keywords

ASJC Scopus subject areas

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