Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins

Seung Whan Kim; Han Jong Kim; Dong Ju Jung; Soo Kyung Lee; Youn Sung Kim; Jae Hong Kim; Tae Sung Kim; Jae Woon Lee

doi:10.1038/sj.onc.1204695

Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins

Seung Whan Kim, Han Jong Kim, Dong Ju Jung, Soo Kyung Lee, Youn Sung Kim, Jae Hong Kim, Tae Sung Kim, Jae Woon Lee

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Transcriptional coactivators SRC-1 and p300 specifically interact with liganded-nuclear receptors and also modulate other transcription factors, including serum response factor (SRF). Here, we report that retinoids repress transactivation by SRF and specific interactions exist between the DNA binding domains of SRF and retinoic acid and retinoid X receptors. We further demonstrate that the repression may involve retinoid-dependent competition for a limiting amount of SRC-1 and p300 between SRF and retinoid receptors. We propose that the well-defined anti-proliferative action of retinoids could, at least in part, result from this novel transrepressive action on the mitogenic transcription factor SRF.

Original language	English (US)
Pages (from-to)	6638-6642
Number of pages	5
Journal	Oncogene
Volume	20
Issue number	45
DOIs	https://doi.org/10.1038/sj.onc.1204695
State	Published - Oct 4 2001
Externally published	Yes

Keywords

Coactivator
Nuclear receptors
Retinoids
SRF
Transcription

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1038/sj.onc.1204695

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title = "Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins",

abstract = "Transcriptional coactivators SRC-1 and p300 specifically interact with liganded-nuclear receptors and also modulate other transcription factors, including serum response factor (SRF). Here, we report that retinoids repress transactivation by SRF and specific interactions exist between the DNA binding domains of SRF and retinoic acid and retinoid X receptors. We further demonstrate that the repression may involve retinoid-dependent competition for a limiting amount of SRC-1 and p300 between SRF and retinoid receptors. We propose that the well-defined anti-proliferative action of retinoids could, at least in part, result from this novel transrepressive action on the mitogenic transcription factor SRF.",

keywords = "Coactivator, Nuclear receptors, Retinoids, SRF, Transcription",

author = "Kim, {Seung Whan} and Kim, {Han Jong} and Jung, {Dong Ju} and Lee, {Soo Kyung} and Kim, {Youn Sung} and Kim, {Jae Hong} and Kim, {Tae Sung} and Lee, {Jae Woon}",

note = "Funding Information: We thank Drs Larry Jameson and Richard Treisman for plasmids. This research was exclusively supported by a grant from the National Creative Research Initiatives Program of the Korean Ministry of Science and Technology.",

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T1 - Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins

AU - Kim, Seung Whan

AU - Kim, Han Jong

AU - Jung, Dong Ju

AU - Lee, Soo Kyung

AU - Kim, Youn Sung

AU - Kim, Jae Hong

AU - Kim, Tae Sung

AU - Lee, Jae Woon

N1 - Funding Information: We thank Drs Larry Jameson and Richard Treisman for plasmids. This research was exclusively supported by a grant from the National Creative Research Initiatives Program of the Korean Ministry of Science and Technology.

PY - 2001/10/4

Y1 - 2001/10/4

N2 - Transcriptional coactivators SRC-1 and p300 specifically interact with liganded-nuclear receptors and also modulate other transcription factors, including serum response factor (SRF). Here, we report that retinoids repress transactivation by SRF and specific interactions exist between the DNA binding domains of SRF and retinoic acid and retinoid X receptors. We further demonstrate that the repression may involve retinoid-dependent competition for a limiting amount of SRC-1 and p300 between SRF and retinoid receptors. We propose that the well-defined anti-proliferative action of retinoids could, at least in part, result from this novel transrepressive action on the mitogenic transcription factor SRF.

AB - Transcriptional coactivators SRC-1 and p300 specifically interact with liganded-nuclear receptors and also modulate other transcription factors, including serum response factor (SRF). Here, we report that retinoids repress transactivation by SRF and specific interactions exist between the DNA binding domains of SRF and retinoic acid and retinoid X receptors. We further demonstrate that the repression may involve retinoid-dependent competition for a limiting amount of SRC-1 and p300 between SRF and retinoid receptors. We propose that the well-defined anti-proliferative action of retinoids could, at least in part, result from this novel transrepressive action on the mitogenic transcription factor SRF.

KW - Coactivator

KW - Nuclear receptors

KW - Retinoids

KW - SRF

KW - Transcription

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Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins

Abstract

Keywords

ASJC Scopus subject areas

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