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Revealing the morphology and function of the cochlea and middle ear with optical coherence tomography

  • George W.S. Burwood
  • , Anders Fridberger
  • , Ruikang K. Wang
  • , Alfred L. Nuttall

Research output: Contribution to journalReview articlepeer-review

Abstract

Optical coherence tomography (OCT) has revolutionized physiological studies of the hearing organ, the vibration and morphology of which can now be measured without opening the surrounding bone. In this review, we provide an overview of OCT as used in the otological research, describing advances and different techniques in vibrometry, angiography, and structural imaging.

Original languageEnglish (US)
Pages (from-to)858-881
Number of pages24
JournalQuantitative Imaging in Medicine and Surgery
Volume9
Issue number5
DOIs
StatePublished - 2019

Funding

The authors wish to thank Dr. Suzan Dziennis for critical appraisal of the manuscript, and Dr. Neel Patel for provision of CT imaging of the human cochlea. This review was made with the utmost effort to be comprehensive, and we wish to offer apologies to any authors who have been left out. Funding: AL Nuttall, GW Burwood, A Fridberger-NIDCD R01 000141. RK Wang-NHLBI R01HL093140 and Washington Research Foundation. A Fridberger-Swedish Research Council 2017-06092. AL Nuttall, GW Burwood-NIH DC005983.

FundersFunder number
National Institute of Health National Heart, Lung, and Blood InstituteR01HL093140
National Institute on Deafness and Other Communication Disorders R01DC012546 Xue Zhong Liu National Institute on Deafness and Other Communication Disorders R01DC012115 Xue Zhong Liu National Institute on Deafness and Other Communication Disorders R01DC014427 Ulrich Müller Peter G Barr-Gillespie National Institute on Deafnessand Other Communication Disorders R01DC005965 Ulrich Müller National Institute on Deafness and Other Communication DisordersR01 000141

    Keywords

    • Cochlea
    • Cochlear mechanics
    • Imaging
    • Optical coherence tomography (OCT)
    • Organ of Corti (OoC)
    • Otology

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

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