Review of selenite cataract

Thomas R. Shearer, Larry L. David, Ruth S. Anderson, Mitsuyoshi Azuma

Research output: Contribution to journalArticlepeer-review

118 Scopus citations


Recent advances in understanding the mechanism of selenite cataract have resulted from locating the cleavage sites on proteolyzed βcrystallins from the cataract, mimicking the insolubilization of crystallins found in the cataract in an in. vitro system, studying cataract produced in lenses cultured in selenite, and permanently or temporarily reducing the rate formation of selenite cataract by use of various inhibitors. The present review discusses the selenite cataract as a useful model for understanding the role calcium-induced proteolysis in cataract formation.

Original languageEnglish (US)
Pages (from-to)357-369
Number of pages13
JournalCurrent Eye Research
Issue number4
StatePublished - 1992

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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