Abstract
Rhesus macaque rhadinovirus (RRV) is a gamma-2 herpesvirus that naturally infects rhesus macaque (RM) monkeys and is closely related to human herpesvirus-8 (HHV-8)/Kaposi's sarcoma-associated herpesvirus (KSHV). Infection of immunodeficient RM induces disease in infected RM that resembles KSHV-associated pathologies. Importantly, RRV possesses homologues of KSHV ORFs that are postulated to play a role in disease development. As such, RRV has emerged as a prominent in vivo model system for examining mechanisms of infection and disease of these pathogenic herpesviruses, and has provided unique insight into how these viruses cause disease.
Original language | English (US) |
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Pages (from-to) | 245-250 |
Number of pages | 6 |
Journal | Current Opinion in Virology |
Volume | 3 |
Issue number | 3 |
DOIs | |
State | Published - Jun 2013 |
ASJC Scopus subject areas
- Virology