Rheumatic Manifestations of Cancer

Judith F. Ashouri, David I. Daikh

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


The wide range of rheumatic and musculoskeletal conditions that can appear in association with cancer emphasizes that rheumatic disease is a major component of the spectrum of paraneoplastic manifestations. Although the pathogenetic mechanisms by which neoplasia causes these manifestations are only partially understood in select cases, many are because of immune-mediated effects stimulated by tumor antigens of endocrine factors produced by tumors. The broad overlap in signs and symptoms of occult malignancy and systemic rheumatic disease emphasizes the importance of considering and investigating the possibility of occult malignancy in the evaluation of patients with these symptoms.

Original languageEnglish (US)
Pages (from-to)489-505
Number of pages17
JournalRheumatic Disease Clinics of North America
Issue number4
StatePublished - Nov 2011
Externally publishedYes


  • Fasciitis
  • Inflammatory myopathy
  • Malignancy
  • Paraneoplastic manifestation
  • Rheumatic disease

ASJC Scopus subject areas

  • Rheumatology


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