RIFM fragrance ingredient safety assessment, 1-heptanethiol, CAS Registry Number 1639-09-4

A. M. Api; D. Belsito; S. Biserta; D. Botelho; M. Bruze; G. A. Burton; J. Buschmann; M. A. Cancellieri; M. L. Dagli; M. Date; W. Dekant; C. Deodhar; A. D. Fryer; S. Gadhia; L. Jones; K. Joshi; M. Kumar; A. Lapczynski; M. Lavelle; I. Lee; D. C. Liebler; H. Moustakas; M. Na; T. M. Penning; G. Ritacco; J. Romine; N. Sadekar; T. W. Schultz; D. Selechnik; F. Siddiqi; I. G. Sipes; G. Sullivan; Y. Thakkar; Y. Tokura

doi:10.1016/j.fct.2021.112360

RIFM fragrance ingredient safety assessment, 1-heptanethiol, CAS Registry Number 1639-09-4

A. M. Api, D. Belsito, S. Biserta, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. A. Cancellieri, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, A. D. Fryer, S. Gadhia, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I. LeeD. C. Liebler, H. Moustakas, M. Na, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, T. W. Schultz, D. Selechnik, F. Siddiqi, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura

Pulmonary and Critical Care Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

1-Heptanethiol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog 1-octanethiol (CAS # 111-88-6) show that 1-heptanethiol is not expected to be genotoxic and provide a calculated MOE >100 for the reproductive toxicity endpoint. Data on read-across analog dodecanethiol (CAS # 112-55-0) provide a calculated MOE >100 for the repeated dose toxicity endpoint. Data show that there are no safety concerns for 1-heptanethiol for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on UV/Vis spectra for read-across analog methyl mercaptan (CAS # 74-93-1); 1-heptanethiol is not expected to be phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the TTC for a Cramer Class I material; exposure is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; 1-heptanethiol was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.

Original language	English (US)
Article number	112360
Journal	Food and Chemical Toxicology
Volume	153
DOIs	https://doi.org/10.1016/j.fct.2021.112360
State	Published - Jul 2021

ASJC Scopus subject areas

Food Science
Toxicology

Access to Document

10.1016/j.fct.2021.112360

Cite this

Api, A. M., Belsito, D., Biserta, S., Botelho, D., Bruze, M., Burton, G. A., Buschmann, J., Cancellieri, M. A., Dagli, M. L., Date, M., Dekant, W., Deodhar, C., Fryer, A. D., Gadhia, S., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., ... Tokura, Y. (2021). RIFM fragrance ingredient safety assessment, 1-heptanethiol, CAS Registry Number 1639-09-4. Food and Chemical Toxicology, 153, Article 112360. https://doi.org/10.1016/j.fct.2021.112360

Api, AM, Belsito, D, Biserta, S, Botelho, D, Bruze, M, Burton, GA, Buschmann, J, Cancellieri, MA, Dagli, ML, Date, M, Dekant, W, Deodhar, C, Fryer, AD, Gadhia, S, Jones, L, Joshi, K, Kumar, M, Lapczynski, A, Lavelle, M, Lee, I, Liebler, DC, Moustakas, H, Na, M, Penning, TM, Ritacco, G, Romine, J, Sadekar, N, Schultz, TW, Selechnik, D, Siddiqi, F, Sipes, IG, Sullivan, G, Thakkar, Y & Tokura, Y 2021, 'RIFM fragrance ingredient safety assessment, 1-heptanethiol, CAS Registry Number 1639-09-4', Food and Chemical Toxicology, vol. 153, 112360. https://doi.org/10.1016/j.fct.2021.112360

@article{5e2681013d9540c79ee0493925423cca,

title = "RIFM fragrance ingredient safety assessment, 1-heptanethiol, CAS Registry Number 1639-09-4",

abstract = "1-Heptanethiol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog 1-octanethiol (CAS # 111-88-6) show that 1-heptanethiol is not expected to be genotoxic and provide a calculated MOE >100 for the reproductive toxicity endpoint. Data on read-across analog dodecanethiol (CAS # 112-55-0) provide a calculated MOE >100 for the repeated dose toxicity endpoint. Data show that there are no safety concerns for 1-heptanethiol for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on UV/Vis spectra for read-across analog methyl mercaptan (CAS # 74-93-1); 1-heptanethiol is not expected to be phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the TTC for a Cramer Class I material; exposure is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; 1-heptanethiol was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.",

author = "Api, {A. M.} and D. Belsito and S. Biserta and D. Botelho and M. Bruze and Burton, {G. A.} and J. Buschmann and Cancellieri, {M. A.} and Dagli, {M. L.} and M. Date and W. Dekant and C. Deodhar and Fryer, {A. D.} and S. Gadhia and L. Jones and K. Joshi and M. Kumar and A. Lapczynski and M. Lavelle and I. Lee and Liebler, {D. C.} and H. Moustakas and M. Na and Penning, {T. M.} and G. Ritacco and J. Romine and N. Sadekar and Schultz, {T. W.} and D. Selechnik and F. Siddiqi and Sipes, {I. G.} and G. Sullivan and Y. Thakkar and Y. Tokura",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = jul,

doi = "10.1016/j.fct.2021.112360",

language = "English (US)",

volume = "153",

journal = "Food and Chemical Toxicology",

issn = "0278-6915",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - RIFM fragrance ingredient safety assessment, 1-heptanethiol, CAS Registry Number 1639-09-4

AU - Api, A. M.

AU - Belsito, D.

AU - Biserta, S.

AU - Botelho, D.

AU - Bruze, M.

AU - Burton, G. A.

AU - Buschmann, J.

AU - Cancellieri, M. A.

AU - Dagli, M. L.

AU - Date, M.

AU - Dekant, W.

AU - Deodhar, C.

AU - Fryer, A. D.

AU - Gadhia, S.

AU - Jones, L.

AU - Joshi, K.

AU - Kumar, M.

AU - Lapczynski, A.

AU - Lavelle, M.

AU - Lee, I.

AU - Liebler, D. C.

AU - Moustakas, H.

AU - Na, M.

AU - Penning, T. M.

AU - Ritacco, G.

AU - Romine, J.

AU - Sadekar, N.

AU - Schultz, T. W.

AU - Selechnik, D.

AU - Siddiqi, F.

AU - Sipes, I. G.

AU - Sullivan, G.

AU - Thakkar, Y.

AU - Tokura, Y.

PY - 2021/7

Y1 - 2021/7

N2 - 1-Heptanethiol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog 1-octanethiol (CAS # 111-88-6) show that 1-heptanethiol is not expected to be genotoxic and provide a calculated MOE >100 for the reproductive toxicity endpoint. Data on read-across analog dodecanethiol (CAS # 112-55-0) provide a calculated MOE >100 for the repeated dose toxicity endpoint. Data show that there are no safety concerns for 1-heptanethiol for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on UV/Vis spectra for read-across analog methyl mercaptan (CAS # 74-93-1); 1-heptanethiol is not expected to be phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the TTC for a Cramer Class I material; exposure is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; 1-heptanethiol was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.

AB - 1-Heptanethiol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog 1-octanethiol (CAS # 111-88-6) show that 1-heptanethiol is not expected to be genotoxic and provide a calculated MOE >100 for the reproductive toxicity endpoint. Data on read-across analog dodecanethiol (CAS # 112-55-0) provide a calculated MOE >100 for the repeated dose toxicity endpoint. Data show that there are no safety concerns for 1-heptanethiol for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on UV/Vis spectra for read-across analog methyl mercaptan (CAS # 74-93-1); 1-heptanethiol is not expected to be phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the TTC for a Cramer Class I material; exposure is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; 1-heptanethiol was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.

UR - http://www.scopus.com/inward/record.url?scp=85109088815&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85109088815&partnerID=8YFLogxK

U2 - 10.1016/j.fct.2021.112360

DO - 10.1016/j.fct.2021.112360

M3 - Article

C2 - 34182040

AN - SCOPUS:85109088815

SN - 0278-6915

VL - 153

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

M1 - 112360

ER -

RIFM fragrance ingredient safety assessment, 1-heptanethiol, CAS Registry Number 1639-09-4

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this