RIFM fragrance ingredient safety assessment, methyl 2-octynoate, CAS Registry Number 111-12-6

A. M. Api; D. Belsito; S. Biserta; D. Botelho; M. Bruze; G. A. Burton; J. Buschmann; M. A. Cancellieri; M. L. Dagli; M. Date; W. Dekant; C. Deodhar; A. D. Fryer; S. Gadhia; L. Jones; K. Joshi; A. Lapczynski; M. Lavelle; D. C. Liebler; M. Na; D. O'Brien; A. Patel; T. M. Penning; G. Ritacco; F. Rodriguez-Ropero; J. Romine; N. Sadekar; D. Salvito; T. W. Schultz; F. Siddiqi; I. G. Sipes; G. Sullivan; Y. Thakkar; Y. Tokura; S. Tsang

doi:10.1016/j.fct.2019.110825

RIFM fragrance ingredient safety assessment, methyl 2-octynoate, CAS Registry Number 111-12-6

A. M. Api, D. Belsito, S. Biserta, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. A. Cancellieri, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, A. D. Fryer, S. Gadhia, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, D. C. Liebler, M. NaD. O'Brien, A. Patel, T. M. Penning, G. Ritacco, F. Rodriguez-Ropero, J. Romine, N. Sadekar, D. Salvito, T. W. Schultz, F. Siddiqi, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura, S. Tsang

Pulmonary and Critical Care Medicine

Research output: Contribution to journal › Short survey › peer-review

Abstract

Methyl 2-octynoate was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that methyl 2-octynoate is not genotoxic. Data provided methyl 2-octynoate a NESIL of 110 μg/cm² for the skin sensitization endpoint. The repeated dose, developmental and reproductive, and local respiratory toxicity endpoints were evaluated using the TTC for a Cramer Class II material, and the exposure to methyl 2-octynoate is below the TTC (0.009 mg/kg/day, 0.009 mg/kg/day, and 0.47 mg/day, respectively). The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; methyl 2-octynoate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; methyl 2-octynoate was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.

Original language	English (US)
Article number	110825
Journal	Food and Chemical Toxicology
Volume	134
DOIs	https://doi.org/10.1016/j.fct.2019.110825
State	Published - Dec 2019

ASJC Scopus subject areas

Food Science
Toxicology

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10.1016/j.fct.2019.110825

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Api, A. M., Belsito, D., Biserta, S., Botelho, D., Bruze, M., Burton, G. A., Buschmann, J., Cancellieri, M. A., Dagli, M. L., Date, M., Dekant, W., Deodhar, C., Fryer, A. D., Gadhia, S., Jones, L., Joshi, K., Lapczynski, A., Lavelle, M., Liebler, D. C., ... Tsang, S. (2019). RIFM fragrance ingredient safety assessment, methyl 2-octynoate, CAS Registry Number 111-12-6. Food and Chemical Toxicology, 134, Article 110825. https://doi.org/10.1016/j.fct.2019.110825

Api, AM, Belsito, D, Biserta, S, Botelho, D, Bruze, M, Burton, GA, Buschmann, J, Cancellieri, MA, Dagli, ML, Date, M, Dekant, W, Deodhar, C, Fryer, AD, Gadhia, S, Jones, L, Joshi, K, Lapczynski, A, Lavelle, M, Liebler, DC, Na, M, O'Brien, D, Patel, A, Penning, TM, Ritacco, G, Rodriguez-Ropero, F, Romine, J, Sadekar, N, Salvito, D, Schultz, TW, Siddiqi, F, Sipes, IG, Sullivan, G, Thakkar, Y, Tokura, Y & Tsang, S 2019, 'RIFM fragrance ingredient safety assessment, methyl 2-octynoate, CAS Registry Number 111-12-6', Food and Chemical Toxicology, vol. 134, 110825. https://doi.org/10.1016/j.fct.2019.110825

@article{6439e96b0eff4005a3e18040f669439d,

title = "RIFM fragrance ingredient safety assessment, methyl 2-octynoate, CAS Registry Number 111-12-6",

abstract = "Methyl 2-octynoate was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that methyl 2-octynoate is not genotoxic. Data provided methyl 2-octynoate a NESIL of 110 μg/cm2 for the skin sensitization endpoint. The repeated dose, developmental and reproductive, and local respiratory toxicity endpoints were evaluated using the TTC for a Cramer Class II material, and the exposure to methyl 2-octynoate is below the TTC (0.009 mg/kg/day, 0.009 mg/kg/day, and 0.47 mg/day, respectively). The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; methyl 2-octynoate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; methyl 2-octynoate was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.",

author = "Api, {A. M.} and D. Belsito and S. Biserta and D. Botelho and M. Bruze and Burton, {G. A.} and J. Buschmann and Cancellieri, {M. A.} and Dagli, {M. L.} and M. Date and W. Dekant and C. Deodhar and Fryer, {A. D.} and S. Gadhia and L. Jones and K. Joshi and A. Lapczynski and M. Lavelle and Liebler, {D. C.} and M. Na and D. O'Brien and A. Patel and Penning, {T. M.} and G. Ritacco and F. Rodriguez-Ropero and J. Romine and N. Sadekar and D. Salvito and Schultz, {T. W.} and F. Siddiqi and Sipes, {I. G.} and G. Sullivan and Y. Thakkar and Y. Tokura and S. Tsang",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = dec,

doi = "10.1016/j.fct.2019.110825",

language = "English (US)",

volume = "134",

journal = "Food and Chemical Toxicology",

issn = "0278-6915",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - RIFM fragrance ingredient safety assessment, methyl 2-octynoate, CAS Registry Number 111-12-6

AU - Api, A. M.

AU - Belsito, D.

AU - Biserta, S.

AU - Botelho, D.

AU - Bruze, M.

AU - Burton, G. A.

AU - Buschmann, J.

AU - Cancellieri, M. A.

AU - Dagli, M. L.

AU - Date, M.

AU - Dekant, W.

AU - Deodhar, C.

AU - Fryer, A. D.

AU - Gadhia, S.

AU - Jones, L.

AU - Joshi, K.

AU - Lapczynski, A.

AU - Lavelle, M.

AU - Liebler, D. C.

AU - Na, M.

AU - O'Brien, D.

AU - Patel, A.

AU - Penning, T. M.

AU - Ritacco, G.

AU - Rodriguez-Ropero, F.

AU - Romine, J.

AU - Sadekar, N.

AU - Salvito, D.

AU - Schultz, T. W.

AU - Siddiqi, F.

AU - Sipes, I. G.

AU - Sullivan, G.

AU - Thakkar, Y.

AU - Tokura, Y.

AU - Tsang, S.

PY - 2019/12

Y1 - 2019/12

N2 - Methyl 2-octynoate was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that methyl 2-octynoate is not genotoxic. Data provided methyl 2-octynoate a NESIL of 110 μg/cm2 for the skin sensitization endpoint. The repeated dose, developmental and reproductive, and local respiratory toxicity endpoints were evaluated using the TTC for a Cramer Class II material, and the exposure to methyl 2-octynoate is below the TTC (0.009 mg/kg/day, 0.009 mg/kg/day, and 0.47 mg/day, respectively). The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; methyl 2-octynoate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; methyl 2-octynoate was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.

AB - Methyl 2-octynoate was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that methyl 2-octynoate is not genotoxic. Data provided methyl 2-octynoate a NESIL of 110 μg/cm2 for the skin sensitization endpoint. The repeated dose, developmental and reproductive, and local respiratory toxicity endpoints were evaluated using the TTC for a Cramer Class II material, and the exposure to methyl 2-octynoate is below the TTC (0.009 mg/kg/day, 0.009 mg/kg/day, and 0.47 mg/day, respectively). The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; methyl 2-octynoate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; methyl 2-octynoate was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.

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U2 - 10.1016/j.fct.2019.110825

DO - 10.1016/j.fct.2019.110825

M3 - Short survey

C2 - 31542434

AN - SCOPUS:85076456171

SN - 0278-6915

VL - 134

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

M1 - 110825

ER -

RIFM fragrance ingredient safety assessment, methyl 2-octynoate, CAS Registry Number 111-12-6

Abstract

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