RIFM fragrance ingredient safety assessment, propyl propionate, CAS Registry Number 106-36-5

A. M. Api; D. Belsito; S. Biserta; D. Botelho; M. Bruze; G. A. Burton; J. Buschmann; M. A. Cancellieri; M. L. Dagli; M. Date; W. Dekant; C. Deodhar; A. D. Fryer; S. Gadhia; L. Jones; K. Joshi; A. Lapczynski; M. Lavelle; D. C. Liebler; M. Na; D. O'Brien; A. Patel; T. M. Penning; G. Ritacco; F. Rodriguez-Ropero; J. Romine; N. Sadekar; D. Salvito; T. W. Schultz; F. Siddiqi; I. G. Sipes; G. Sullivan; Y. Thakkar; Y. Tokura; S. Tsang

doi:10.1016/j.fct.2020.111763

RIFM fragrance ingredient safety assessment, propyl propionate, CAS Registry Number 106-36-5

A. M. Api, D. Belsito, S. Biserta, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. A. Cancellieri, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, A. D. Fryer, S. Gadhia, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, D. C. Liebler, M. NaD. O'Brien, A. Patel, T. M. Penning, G. Ritacco, F. Rodriguez-Ropero, J. Romine, N. Sadekar, D. Salvito, T. W. Schultz, F. Siddiqi, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura, S. Tsang

Pulmonary and Critical Care Medicine

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Summary: The existing information supports the use of this material as described in this safety assessment. Propyl propionate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that propyl propionate is not genotoxic. Data on propyl propionate provide a calculated margin of exposure (MOE) >100 for the repeated dose toxicity, reproductive toxicity, and local respiratory toxicity endpoints. Data from read-across analog pentyl propionate (CAS # 624-54-4) show that there are no safety concerns for propyl propionate for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; propyl propionate is not expected to be phototoxic/photoallergenic. For the hazard assessment based on the screening data, propyl propionate is not persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards. For the risk assessment, propyl propionate was not able to be risk screened as there were no reported volumes of use for either North America or Europe in the 2015 IFRA Survey.

Original language	English (US)
Article number	111763
Journal	Food and Chemical Toxicology
Volume	146
DOIs	https://doi.org/10.1016/j.fct.2020.111763
State	Published - Dec 15 2020

Keywords

Environmental safety
Genotoxicity
Local respiratory toxicity
Phototoxicity/photoallergenicity
Repeated dose, developmental, and reproductive toxicity
Skin sensitization

ASJC Scopus subject areas

Food Science
Toxicology

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10.1016/j.fct.2020.111763

Cite this

Api, A. M., Belsito, D., Biserta, S., Botelho, D., Bruze, M., Burton, G. A., Buschmann, J., Cancellieri, M. A., Dagli, M. L., Date, M., Dekant, W., Deodhar, C., Fryer, A. D., Gadhia, S., Jones, L., Joshi, K., Lapczynski, A., Lavelle, M., Liebler, D. C., ... Tsang, S. (2020). RIFM fragrance ingredient safety assessment, propyl propionate, CAS Registry Number 106-36-5. Food and Chemical Toxicology, 146, Article 111763. https://doi.org/10.1016/j.fct.2020.111763

Api, AM, Belsito, D, Biserta, S, Botelho, D, Bruze, M, Burton, GA, Buschmann, J, Cancellieri, MA, Dagli, ML, Date, M, Dekant, W, Deodhar, C, Fryer, AD, Gadhia, S, Jones, L, Joshi, K, Lapczynski, A, Lavelle, M, Liebler, DC, Na, M, O'Brien, D, Patel, A, Penning, TM, Ritacco, G, Rodriguez-Ropero, F, Romine, J, Sadekar, N, Salvito, D, Schultz, TW, Siddiqi, F, Sipes, IG, Sullivan, G, Thakkar, Y, Tokura, Y & Tsang, S 2020, 'RIFM fragrance ingredient safety assessment, propyl propionate, CAS Registry Number 106-36-5', Food and Chemical Toxicology, vol. 146, 111763. https://doi.org/10.1016/j.fct.2020.111763

@article{f031de403f554b23b9c9db47915caea0,

title = "RIFM fragrance ingredient safety assessment, propyl propionate, CAS Registry Number 106-36-5",

abstract = "Summary: The existing information supports the use of this material as described in this safety assessment. Propyl propionate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that propyl propionate is not genotoxic. Data on propyl propionate provide a calculated margin of exposure (MOE) >100 for the repeated dose toxicity, reproductive toxicity, and local respiratory toxicity endpoints. Data from read-across analog pentyl propionate (CAS # 624-54-4) show that there are no safety concerns for propyl propionate for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; propyl propionate is not expected to be phototoxic/photoallergenic. For the hazard assessment based on the screening data, propyl propionate is not persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards. For the risk assessment, propyl propionate was not able to be risk screened as there were no reported volumes of use for either North America or Europe in the 2015 IFRA Survey.",

keywords = "Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, developmental, and reproductive toxicity, Skin sensitization",

author = "Api, {A. M.} and D. Belsito and S. Biserta and D. Botelho and M. Bruze and Burton, {G. A.} and J. Buschmann and Cancellieri, {M. A.} and Dagli, {M. L.} and M. Date and W. Dekant and C. Deodhar and Fryer, {A. D.} and S. Gadhia and L. Jones and K. Joshi and A. Lapczynski and M. Lavelle and Liebler, {D. C.} and M. Na and D. O'Brien and A. Patel and Penning, {T. M.} and G. Ritacco and F. Rodriguez-Ropero and J. Romine and N. Sadekar and D. Salvito and Schultz, {T. W.} and F. Siddiqi and Sipes, {I. G.} and G. Sullivan and Y. Thakkar and Y. Tokura and S. Tsang",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = dec,

day = "15",

doi = "10.1016/j.fct.2020.111763",

language = "English (US)",

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T1 - RIFM fragrance ingredient safety assessment, propyl propionate, CAS Registry Number 106-36-5

AU - Api, A. M.

AU - Belsito, D.

AU - Biserta, S.

AU - Botelho, D.

AU - Bruze, M.

AU - Burton, G. A.

AU - Buschmann, J.

AU - Cancellieri, M. A.

AU - Dagli, M. L.

AU - Date, M.

AU - Dekant, W.

AU - Deodhar, C.

AU - Fryer, A. D.

AU - Gadhia, S.

AU - Jones, L.

AU - Joshi, K.

AU - Lapczynski, A.

AU - Lavelle, M.

AU - Liebler, D. C.

AU - Na, M.

AU - O'Brien, D.

AU - Patel, A.

AU - Penning, T. M.

AU - Ritacco, G.

AU - Rodriguez-Ropero, F.

AU - Romine, J.

AU - Sadekar, N.

AU - Salvito, D.

AU - Schultz, T. W.

AU - Siddiqi, F.

AU - Sipes, I. G.

AU - Sullivan, G.

AU - Thakkar, Y.

AU - Tokura, Y.

AU - Tsang, S.

PY - 2020/12/15

Y1 - 2020/12/15

N2 - Summary: The existing information supports the use of this material as described in this safety assessment. Propyl propionate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that propyl propionate is not genotoxic. Data on propyl propionate provide a calculated margin of exposure (MOE) >100 for the repeated dose toxicity, reproductive toxicity, and local respiratory toxicity endpoints. Data from read-across analog pentyl propionate (CAS # 624-54-4) show that there are no safety concerns for propyl propionate for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; propyl propionate is not expected to be phototoxic/photoallergenic. For the hazard assessment based on the screening data, propyl propionate is not persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards. For the risk assessment, propyl propionate was not able to be risk screened as there were no reported volumes of use for either North America or Europe in the 2015 IFRA Survey.

AB - Summary: The existing information supports the use of this material as described in this safety assessment. Propyl propionate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that propyl propionate is not genotoxic. Data on propyl propionate provide a calculated margin of exposure (MOE) >100 for the repeated dose toxicity, reproductive toxicity, and local respiratory toxicity endpoints. Data from read-across analog pentyl propionate (CAS # 624-54-4) show that there are no safety concerns for propyl propionate for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; propyl propionate is not expected to be phototoxic/photoallergenic. For the hazard assessment based on the screening data, propyl propionate is not persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards. For the risk assessment, propyl propionate was not able to be risk screened as there were no reported volumes of use for either North America or Europe in the 2015 IFRA Survey.

KW - Environmental safety

KW - Genotoxicity

KW - Local respiratory toxicity

KW - Phototoxicity/photoallergenicity

KW - Repeated dose, developmental, and reproductive toxicity

KW - Skin sensitization

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U2 - 10.1016/j.fct.2020.111763

DO - 10.1016/j.fct.2020.111763

M3 - Short survey

C2 - 32971211

AN - SCOPUS:85091712798

SN - 0278-6915

VL - 146

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

M1 - 111763

ER -

RIFM fragrance ingredient safety assessment, propyl propionate, CAS Registry Number 106-36-5

Abstract

Keywords

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