Original language | English (US) |
---|---|
Article number | 112912 |
Journal | Food and Chemical Toxicology |
Volume | 161 |
DOIs | |
State | Published - Mar 2022 |
ASJC Scopus subject areas
- Food Science
- Toxicology
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In: Food and Chemical Toxicology, Vol. 161, 112912, 03.2022.
Research output: Contribution to journal › Short survey › peer-review
}
TY - JOUR
T1 - RIFM fragrance ingredient safety assessment, (−)-(R)-α-phellandrene, CAS Registry Number 4221-98-1
AU - Api, A. M.
AU - Belsito, D.
AU - Botelho, D.
AU - Bruze, M.
AU - Burton, G. A.
AU - Buschmann, J.
AU - Cancellieri, M. A.
AU - Dagli, M. L.
AU - Date, M.
AU - Dekant, W.
AU - Deodhar, C.
AU - Fryer, A. D.
AU - Jones, L.
AU - Joshi, K.
AU - Kumar, M.
AU - Lapczynski, A.
AU - Lavelle, M.
AU - Lee, I.
AU - Liebler, D. C.
AU - Moustakas, H.
AU - Na, M.
AU - Penning, T. M.
AU - Ritacco, G.
AU - Romine, J.
AU - Sadekar, N.
AU - Schultz, T. W.
AU - Selechnik, D.
AU - Siddiqi, F.
AU - Sipes, I. G.
AU - Sullivan, G.
AU - Thakkar, Y.
AU - Tokura, Y.
N1 - Funding Information: There are insufficient repeated dose toxicity data on 2-tridecenal. Read-across material hexen-2-al (CAS # 6728-26-3; see Section VI) has sufficient data to support the repeated dose toxicity endpoint. In a non-GLP and non-guideline subchronic study, 15 CFE rats/sex/dose were fed diets containing 0, 260, 640, 1600, or 4000 ppm hexen-2-al for 13 weeks (equivalent to 0, 13, 32, 80, or 200 mg/kg/day, respectively). No treatment-related mortality was reported for any dose group. No treatment-related changes in food consumption, bodyweight parameter, hematology, clinical chemistry, organ weights, and histopathology were reported. There was a slight increase in male urine volume with a concurrent decrease in the specific gravity of urine at the highest dose, but there were no alterations in kidney weight or histopathology. In the high-dose group females, ovary weight was significantly increased but without any correlating histopathological changes. Hence, these effects were not considered to be treatment-related adverse effects. Based on the lack of any treatment-related adverse effects at the highest tested dose, the NOAEL for repeated dose toxicity was considered to be 4000 ppm or 200 mg/kg/day.
PY - 2022/3
Y1 - 2022/3
UR - http://www.scopus.com/inward/record.url?scp=85126314129&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85126314129&partnerID=8YFLogxK
U2 - 10.1016/j.fct.2022.112912
DO - 10.1016/j.fct.2022.112912
M3 - Short survey
C2 - 35278499
AN - SCOPUS:85126314129
SN - 0278-6915
VL - 161
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
M1 - 112912
ER -