TY - JOUR
T1 - Risk of Zika microcephaly correlates with features of maternal antibodies
AU - Robbiani, Davide F.
AU - Olsen, Priscilla C.
AU - Costa, Federico
AU - Wang, Qiao
AU - Oliveira, Thiago Y.
AU - Nery, Nivison
AU - Aromolaran, Adeolu
AU - do Rosário, Mateus S.
AU - Sacramento, Gielson A.
AU - Cruz, Jaqueline S.
AU - Khouri, Ricardo
AU - Wunder, Elsio A.
AU - Mattos, Adriana
AU - de Paula Freitas, Bruno
AU - Sarno, Manoel
AU - Archanjo, Gracinda
AU - Daltro, Dina
AU - Carvalho, Gustavo B.S.
AU - Pimentel, Kleber
AU - de Siqueira, Isadora C.
AU - de Almeida, João R.M.
AU - Henriques, Daniele F.
AU - Lima, Juliana A.
AU - Vasconcelos, Pedro F.C.
AU - Schaefer-Babajew, Dennis
AU - Azzopardi, Stephanie A.
AU - Bozzacco, Leonia
AU - Gazumyan, Anna
AU - Belfort, Rubens
AU - Alcântara, Ana P.
AU - Carvalho, Gustavo
AU - Moreira, Licia
AU - Araujo, Katiaci
AU - Reis, Mitermayer G.
AU - Keesler, Rebekah I.
AU - Coffey, Lark L.
AU - Tisoncik-Go, Jennifer
AU - Gale, Michael
AU - Rajagopal, Lakshmi
AU - Adams Waldorf, Kristina M.
AU - Dudley, Dawn M.
AU - Simmons, Heather A.
AU - Mejia, Andres
AU - O’Connor, David H.
AU - Steinbach, Rosemary J.
AU - Haese, Nicole
AU - Smith, Jessica
AU - Lewis, Anne
AU - Colgin, Lois
AU - Roberts, Victoria
AU - Frias, Antonio
AU - Kelleher, Meredith
AU - Hirsch, Alec
AU - Streblow, Daniel N.
AU - Rice, Charles M.
AU - MacDonald, Margaret R.
AU - de Almeida, Antonio R.P.
AU - van Rompay, Koen K.A.
AU - Ko, Albert I.
AU - Nussenzweig, Michel C.
N1 - Publisher Copyright:
© 2019 Robbiani et al.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015–2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly.
AB - Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015–2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly.
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U2 - 10.1084/jem.20191061
DO - 10.1084/jem.20191061
M3 - Article
C2 - 31413072
AN - SCOPUS:85072993593
SN - 0022-1007
VL - 216
SP - 2302
EP - 2315
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 10
ER -