Abstract
The insulin-like growth factor (IGF) system is comprised of receptors, ligands (IGF-I and IGF-II), and a family of binding proteins (IGFBPs). It plays an important role in growth and development and in the maintenance of normal homeostasis. We present a review of the current laboratory and epidemiologic evidence that suggests an important role of the IGF system in colorectal carcinogenesis. Due to the complexity of this system, we have focused the review on the role of the IGF-1 receptor and its ligands in colorectal carcinogenesis and the strategies to block this pathway as a potential anti-cancer therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 91-98 |
| Number of pages | 8 |
| Journal | Critical Reviews in Oncology/Hematology |
| Volume | 66 |
| Issue number | 2 |
| DOIs | |
| State | Published - May 2008 |
| Externally published | Yes |
Funding
This research was supported by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research, Bethesda, MD, United States.
| Funders |
|---|
| Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health |
| National Institute of Health-National Cancer Institute |
Keywords
- Acromegaly
- Anti-IGF therapy
- Epidemiologic studies in cancer
- Growth factors
ASJC Scopus subject areas
- Hematology
- Oncology
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