Role of pancreatic enzymes in the development of multiple organ failure after shock

Darren J. Malinoski; Cristobol Barrios; Hubert D. Kim; Jose A. Acosta; Geert W. Schmid-Schonbein; Tony E. Hugli; Raul Coimbra; David B. Hoyt

doi:10.1080/17471060801925288

Role of pancreatic enzymes in the development of multiple organ failure after shock

Darren J. Malinoski, Cristobol Barrios, Hubert D. Kim, Jose A. Acosta, Geert W. Schmid-Schonbein, Tony E. Hugli, Raul Coimbra, David B. Hoyt

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

The gastrointestinal tract has been implicated as one of the main organ systems involved in the initiation of the acute inflammatory response that often follows shock. The exocrine functions of the pancreas include the secretion of digestive enzymes into the duodenal lumen. These intraluminal pancreatic enzymes may play a pivotal role in the pathogenesis of multiorgan failure after shock. This article reviews the literature surrounding the hypothesis that digestive enzymes produced by the pancreas are involved in the initiation of the systemic inflammatory response after shock and, ultimately, contribute to multiorgan failure and death.

Original language	English (US)
Pages (from-to)	161-167
Number of pages	7
Journal	Journal of Organ Dysfunction
Volume	4
Issue number	3
DOIs	https://doi.org/10.1080/17471060801925288
State	Published - 2008
Externally published	Yes

Keywords

Inflammation
Pancreas
Pancreatic duct ligation
Proteases
Serine protease inhibitors
Shock

ASJC Scopus subject areas

Physiology
Molecular Biology
Critical Care
Critical Care and Intensive Care Medicine

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10.1080/17471060801925288

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title = "Role of pancreatic enzymes in the development of multiple organ failure after shock",

abstract = "The gastrointestinal tract has been implicated as one of the main organ systems involved in the initiation of the acute inflammatory response that often follows shock. The exocrine functions of the pancreas include the secretion of digestive enzymes into the duodenal lumen. These intraluminal pancreatic enzymes may play a pivotal role in the pathogenesis of multiorgan failure after shock. This article reviews the literature surrounding the hypothesis that digestive enzymes produced by the pancreas are involved in the initiation of the systemic inflammatory response after shock and, ultimately, contribute to multiorgan failure and death.",

keywords = "Inflammation, Pancreas, Pancreatic duct ligation, Proteases, Serine protease inhibitors, Shock",

author = "Malinoski, {Darren J.} and Cristobol Barrios and Kim, {Hubert D.} and Acosta, {Jose A.} and Schmid-Schonbein, {Geert W.} and Hugli, {Tony E.} and Raul Coimbra and Hoyt, {David B.}",

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T1 - Role of pancreatic enzymes in the development of multiple organ failure after shock

AU - Malinoski, Darren J.

AU - Barrios, Cristobol

AU - Kim, Hubert D.

AU - Acosta, Jose A.

AU - Schmid-Schonbein, Geert W.

AU - Hugli, Tony E.

AU - Coimbra, Raul

AU - Hoyt, David B.

PY - 2008

Y1 - 2008

N2 - The gastrointestinal tract has been implicated as one of the main organ systems involved in the initiation of the acute inflammatory response that often follows shock. The exocrine functions of the pancreas include the secretion of digestive enzymes into the duodenal lumen. These intraluminal pancreatic enzymes may play a pivotal role in the pathogenesis of multiorgan failure after shock. This article reviews the literature surrounding the hypothesis that digestive enzymes produced by the pancreas are involved in the initiation of the systemic inflammatory response after shock and, ultimately, contribute to multiorgan failure and death.

AB - The gastrointestinal tract has been implicated as one of the main organ systems involved in the initiation of the acute inflammatory response that often follows shock. The exocrine functions of the pancreas include the secretion of digestive enzymes into the duodenal lumen. These intraluminal pancreatic enzymes may play a pivotal role in the pathogenesis of multiorgan failure after shock. This article reviews the literature surrounding the hypothesis that digestive enzymes produced by the pancreas are involved in the initiation of the systemic inflammatory response after shock and, ultimately, contribute to multiorgan failure and death.

KW - Inflammation

KW - Pancreas

KW - Pancreatic duct ligation

KW - Proteases

KW - Serine protease inhibitors

KW - Shock

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DO - 10.1080/17471060801925288

M3 - Review article

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EP - 167

JO - Journal of Organ Dysfunction

JF - Journal of Organ Dysfunction

IS - 3

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Role of pancreatic enzymes in the development of multiple organ failure after shock

Abstract

Keywords

ASJC Scopus subject areas

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