Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation

Chang Xia, Xiaoquan Rao, Jixin Zhong

Research output: Contribution to journalReview articlepeer-review

146 Scopus citations


Although a critical role of adaptive immune system has been confirmed in driving local and systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying mechanism is not completely understood. Inflammatory regulation has been focused on innate immunity especially macrophage for a long time, while increasing evidence suggests T cells are crucial for the development of metabolic inflammation and insulin resistance since 2009. There was growing evidence supporting the critical implication of T cells in the pathogenesis of type 2 diabetes. We will discuss the available effect of T cells subsets in adaptive immune system associated with the procession of T2DM, which may unveil several potential strategies that could provide successful therapies in the future.

Original languageEnglish (US)
Article number6494795
JournalJournal of Diabetes Research
StatePublished - 2017

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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