Role of temperature dependence of optical properties in laser irradiation of biological tissue

S. Rastegar, B. M. Kim, S. L. Jacques

Research output: Chapter in Book/Report/Conference proceedingConference contribution

21 Scopus citations


Optical properties of biological tissue can change as a result of thermal denaturation due to temperature rise; a familiar example is whitening observed in cooking egg-white. Changes in optical properties with temperature have been reported in the literature. Temperature rise due to laser irradiation is a function of the optical properties of tissue which themselves are a function of temperature of the tissue. This creates a coupling between light and temperature fields for biological tissue under laser irradiation. The effects of this coupling on the temperature response and light distribution may play an important role in dosimetry consideration for therapeutic as well as diagnostic application of lasers in medicine. In a previous study this problem was addressed in one dimension, for short irradiation exposures, using certain simplifying assumptions. The purpose of this research was to develop a mathematical model for dynamic optical changes with thermal denaturation and a computer program for simulation of these effects for a multi-dimensional geometry.

Original languageEnglish (US)
Title of host publicationLaser-Tissue Interaction III
EditorsSteven L. Jacques
Number of pages8
ISBN (Electronic)9780819407924
StatePublished - Aug 7 1992
Externally publishedYes
EventLaser-Tissue Interaction III 1992 - Los Angeles, United States
Duration: Jan 19 1992Jan 24 1992

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


OtherLaser-Tissue Interaction III 1992
Country/TerritoryUnited States
CityLos Angeles

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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