Role reversal: The regulation of neuronal gene expression by microRNAs

Matthew E. Klein, Soren Impey, Richard H. Goodman

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


In a similar fashion to transcription factors, non-coding RNAs can be essential regulators of gene expression. The largest class of non-coding RNAs is the microRNAs. These ∼22 nt double-stranded RNA molecules can repress translation or target mRNA degradation. There has been a surge of research in the past year stimulated by the recent availability of specialized techniques, both in vitro and in silico, for predicting and characterizing microRNAs. The accumulating evidence suggests that microRNAs are ubiquitous regulators of gene expression during development. The combined actions of microRNAs and transcription factors are able to tune the expression of proteins on a global level in a manner that cannot be achieved by transcription factors alone.

Original languageEnglish (US)
Pages (from-to)507-513
Number of pages7
JournalCurrent Opinion in Neurobiology
Issue number5
StatePublished - Oct 2005

ASJC Scopus subject areas

  • General Neuroscience


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