Safety of Oral and Intravenous Iron

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations


As the adverse effects of iron deficiency are better recognized, the use of oral and intravenous iron has increased dramatically. Oral iron is often poorly tolerated, with up to 70% or more of patients noting gastrointestinal issues; this may affect adherence to therapy. In addition, many patients will not respond to oral iron due to their underlying illness. Intravenous iron is being used more frequently to replete iron stores. True anaphylaxis is very rare, but complement-mediated infusion reactions may be seen in up to 1 in every 200 patients. Previous concerns about intravenous iron increasing the risk of infection or cardiovascular disease are unfounded.

Original languageEnglish (US)
Pages (from-to)8-12
Number of pages5
JournalActa Haematologica
Issue number1
StatePublished - May 1 2019


  • Hypophosphatemia
  • Iron
  • Microbiome

ASJC Scopus subject areas

  • Hematology


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