Scarring and scarless wound healing

B. J. Larson, A. Nauta, K. Kawai, M. T. Longaker, H. P. Lorenz

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


In contrast to adult wound healing, the early-gestation fetus has the remarkable ability to heal skin wounds without scar formation. Over the past several decades, an intensive research effort has greatly increased our understanding of scarless fetal wound healing. This chapter discusses the differences that exist between the extracellular matrix (ECM), inflammatory response, cellular mediators, stem cell function, and gene expression profiles of fetal and postnatal wounds. This chapter then reviews the currently available treatment options for scars and concludes with a discussion of future trends in scar treatment.

Original languageEnglish (US)
Title of host publicationAdvanced Wound Repair Therapies
PublisherElsevier Inc.
Number of pages35
ISBN (Print)9781845697006
StatePublished - Jun 2011
Externally publishedYes


  • Fetal wound repair
  • Review
  • Scarless wound healing
  • Skin development
  • Wound healing

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)


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