Selective androgen receptor modulators antagonize apolipoprotein E4-induced cognitive impairments

Summer Acevedo; Luis Gardell; Stefania Risso Bradley; Fabrice Piu; Jacob Raber

doi:10.2174/157018008784619898

Selective androgen receptor modulators antagonize apolipoprotein E4-induced cognitive impairments

Summer Acevedo, Luis Gardell, Stefania Risso Bradley, Fabrice Piu, Jacob Raber

Behavioral Neuroscience

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

While tissue specific effects of selective androgen receptor modulators (SARMs) outside the brain have been reported, little is known about brain specific SARMs. Here we show that SARMs upregulate androgen receptor levels in brain following castration and antagonize impairments in hippocampus-dependent novel location recognition and spatial memory retention in apoE4 female mice. Together with the reduced androgen levels in aged men and women and the beneficial effects of androgens on brain function and pathology in Alzheimer's disease-related models, these data support the therapeutic potential of SARMs for age-related cognitive decline and Alzheimer's disease.

Original language	English (US)
Pages (from-to)	271-276
Number of pages	6
Journal	Letters in Drug Design and Discovery
Volume	5
Issue number	4
DOIs	https://doi.org/10.2174/157018008784619898
State	Published - Jun 2008

Keywords

Androgen receptor
Castration
Mouse
Object recognition
Open field
Water maze

ASJC Scopus subject areas

Molecular Medicine
Pharmaceutical Science
Drug Discovery

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10.2174/157018008784619898

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abstract = "While tissue specific effects of selective androgen receptor modulators (SARMs) outside the brain have been reported, little is known about brain specific SARMs. Here we show that SARMs upregulate androgen receptor levels in brain following castration and antagonize impairments in hippocampus-dependent novel location recognition and spatial memory retention in apoE4 female mice. Together with the reduced androgen levels in aged men and women and the beneficial effects of androgens on brain function and pathology in Alzheimer's disease-related models, these data support the therapeutic potential of SARMs for age-related cognitive decline and Alzheimer's disease.",

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AU - Gardell, Luis

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AU - Piu, Fabrice

AU - Raber, Jacob

PY - 2008/6

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AB - While tissue specific effects of selective androgen receptor modulators (SARMs) outside the brain have been reported, little is known about brain specific SARMs. Here we show that SARMs upregulate androgen receptor levels in brain following castration and antagonize impairments in hippocampus-dependent novel location recognition and spatial memory retention in apoE4 female mice. Together with the reduced androgen levels in aged men and women and the beneficial effects of androgens on brain function and pathology in Alzheimer's disease-related models, these data support the therapeutic potential of SARMs for age-related cognitive decline and Alzheimer's disease.

KW - Androgen receptor

KW - Castration

KW - Mouse

KW - Object recognition

KW - Open field

KW - Water maze

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Selective androgen receptor modulators antagonize apolipoprotein E4-induced cognitive impairments

Abstract

Keywords

ASJC Scopus subject areas

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