@article{783daff5d5ad4c13af44b5a3d08281dc,
title = "Self-Enforcing Feedback Activation between BCL6 and Pre-B Cell Receptor Signaling Defines a Distinct Subtype of Acute Lymphoblastic Leukemia",
abstract = "Studying 830 pre-B ALL cases from four clinical trials, we found that human ALL can be divided into two fundamentally distinct subtypes based on pre-BCR function. While absent in the majority of ALL cases, tonic pre-BCR signaling was found in 112 cases (13.5%). In these cases, tonic pre-BCR signaling induced activation of BCL6, which in turn increased pre-BCR signaling output at the transcriptional level. Interestingly, inhibition of pre-BCR-related tyrosine kinases reduced constitutive BCL6 expression and selectively killed patient-derived pre-BCR+ ALL cells. These findings identify a genetically and phenotypically distinct subset of human ALL that critically depends on tonic pre-BCR signaling. Invivo treatment studies suggested that pre-BCR tyrosine kinase inhibitors are useful for the treatment of patients with pre-BCR+ ALL.",
author = "Huimin Geng and Christian Hurtz and Lenz, {Kyle B.} and Zhengshan Chen and Dirk Baumjohann and Sarah Thompson and Goloviznina, {Natalya A.} and Chen, {Wei Yi} and Jianya Huan and Dorian LaTocha and Erica Ballabio and Gang Xiao and Lee, {Jae Woong} and Anne Deucher and Zhongxia Qi and Eugene Park and Chuanxin Huang and Rahul Nahar and Kweon, {Soo Mi} and Seyedmehdi Shojaee and Chan, {Lai N.} and Jingwei Yu and Kornblau, {Steven M.} and Bijl, {Janetta J.} and Ye, {B. Hilda} and {Mark Ansel}, K. and Elisabeth Paietta and Ari Melnick and Hunger, {Stephen P.} and Peter Kurre and Tyner, {Jeffrey W.} and Loh, {Mignon L.} and Roeder, {Robert G.} and Druker, {Brian J.} and Burger, {Jan A.} and Milne, {Thomas A.} and Chang, {Bill H.} and Markus M{\"u}schen",
note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",
year = "2015",
month = mar,
day = "9",
doi = "10.1016/j.ccell.2015.02.003",
language = "English (US)",
volume = "27",
pages = "409--425",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "3",
}