Sertraline-Associated Cholestasis and Ductopenia Consistent with Vanishing Bile Duct Syndrome

Máire A. Conrad; Jiawei Cui; Henry C. Lin

doi:10.1016/j.jpeds.2015.10.065

Sertraline-Associated Cholestasis and Ductopenia Consistent with Vanishing Bile Duct Syndrome

Máire A. Conrad, Jiawei Cui, Henry C. Lin

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

An adolescent with depression treated with sertraline developed cholestasis and bile duct paucity, which resolved with medication discontinuation. Vanishing bile duct syndrome is an acquired destruction of interlobular bile ducts. This type of drug-induced liver injury has been associated with other medications and requires practitioners' awareness of potential hepatotoxicity.

Original language	English (US)
Pages (from-to)	313-315.e1
Journal	Journal of Pediatrics
Volume	169
DOIs	https://doi.org/10.1016/j.jpeds.2015.10.065
State	Published - Feb 1 2016
Externally published	Yes

Keywords

Dili Drug-induced liver injury
SSRI Selective serotonin reuptake inhibitor
VBDS Vanishing bile duct syndrome

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/j.jpeds.2015.10.065

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title = "Sertraline-Associated Cholestasis and Ductopenia Consistent with Vanishing Bile Duct Syndrome",

abstract = "An adolescent with depression treated with sertraline developed cholestasis and bile duct paucity, which resolved with medication discontinuation. Vanishing bile duct syndrome is an acquired destruction of interlobular bile ducts. This type of drug-induced liver injury has been associated with other medications and requires practitioners' awareness of potential hepatotoxicity.",

keywords = "Dili Drug-induced liver injury, SSRI Selective serotonin reuptake inhibitor, VBDS Vanishing bile duct syndrome",

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AU - Conrad, Máire A.

AU - Cui, Jiawei

AU - Lin, Henry C.

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Y1 - 2016/2/1

N2 - An adolescent with depression treated with sertraline developed cholestasis and bile duct paucity, which resolved with medication discontinuation. Vanishing bile duct syndrome is an acquired destruction of interlobular bile ducts. This type of drug-induced liver injury has been associated with other medications and requires practitioners' awareness of potential hepatotoxicity.

AB - An adolescent with depression treated with sertraline developed cholestasis and bile duct paucity, which resolved with medication discontinuation. Vanishing bile duct syndrome is an acquired destruction of interlobular bile ducts. This type of drug-induced liver injury has been associated with other medications and requires practitioners' awareness of potential hepatotoxicity.

KW - Dili Drug-induced liver injury

KW - SSRI Selective serotonin reuptake inhibitor

KW - VBDS Vanishing bile duct syndrome

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JO - Journal of Pediatrics

JF - Journal of Pediatrics

ER -

Sertraline-Associated Cholestasis and Ductopenia Consistent with Vanishing Bile Duct Syndrome

Abstract

Keywords

ASJC Scopus subject areas

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