Serum alkaline phosphatase levels associate with elevated serum C-reactive protein in chronic kidney disease

Sriharsha Damera; Kalani L. Raphael; Bradley C. Baird; Alfred K. Cheung; Tom Greene; Srinivasan Beddhu

doi:10.1038/ki.2010.356

Serum alkaline phosphatase levels associate with elevated serum C-reactive protein in chronic kidney disease

Sriharsha Damera, Kalani L. Raphael, Bradley C. Baird, Alfred K. Cheung, Tom Greene, Srinivasan Beddhu

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

High serum alkaline phosphatase concentrations are associated with elevated serum C-reactive protein (CRP) levels in the general population. To examine whether this association is independent of serum vitamin D levels or modified in chronic kidney disease (CKD), we determined if such associations exist using data from the National Health and Nutrition Examination Survey III of 14,420 adult participants in which 5.7% had CKD (defined as estimated glomerular filtration rate 60 ml/min per 1.73 m²). For each doubling of serum alkaline phosphatase, the odds of elevated serum CRP (over 3 mg/l) were increased 2.73-fold in the non-chronic and 2.50-fold in the CKD sub-populations, respectively. Regression coefficients of each doubling of serum alkaline phosphatase with elevated CRP were not significantly different in between the sub-populations. Additional adjustment for the serum 25-hydroxy (OH) vitamin D level did not substantively change the results. Thus, associations of serum alkaline phosphatase with elevated CRP are independent of serum 25-OH vitamin D in the chronic and non-CKD populations. Hence, serum alkaline phosphatase might be a marker of the inflammatory milieu.

Original language	English (US)
Pages (from-to)	228-233
Number of pages	6
Journal	Kidney International
Volume	79
Issue number	2
DOIs	https://doi.org/10.1038/ki.2010.356
State	Published - Jan 2011
Externally published	Yes

Keywords

C-reactive protein
alkaline phosphatase
chronic kidney disease
vitamin D

ASJC Scopus subject areas

Nephrology

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10.1038/ki.2010.356

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title = "Serum alkaline phosphatase levels associate with elevated serum C-reactive protein in chronic kidney disease",

abstract = "High serum alkaline phosphatase concentrations are associated with elevated serum C-reactive protein (CRP) levels in the general population. To examine whether this association is independent of serum vitamin D levels or modified in chronic kidney disease (CKD), we determined if such associations exist using data from the National Health and Nutrition Examination Survey III of 14,420 adult participants in which 5.7% had CKD (defined as estimated glomerular filtration rate 60 ml/min per 1.73 m2). For each doubling of serum alkaline phosphatase, the odds of elevated serum CRP (over 3 mg/l) were increased 2.73-fold in the non-chronic and 2.50-fold in the CKD sub-populations, respectively. Regression coefficients of each doubling of serum alkaline phosphatase with elevated CRP were not significantly different in between the sub-populations. Additional adjustment for the serum 25-hydroxy (OH) vitamin D level did not substantively change the results. Thus, associations of serum alkaline phosphatase with elevated CRP are independent of serum 25-OH vitamin D in the chronic and non-CKD populations. Hence, serum alkaline phosphatase might be a marker of the inflammatory milieu.",

keywords = "C-reactive protein, alkaline phosphatase, chronic kidney disease, vitamin D",

author = "Sriharsha Damera and Raphael, {Kalani L.} and Baird, {Bradley C.} and Cheung, {Alfred K.} and Tom Greene and Srinivasan Beddhu",

note = "Funding Information: This work is supported by a grant from the Dialysis Research Foundation of Utah. SB is the recipient of grants RO1-DK077298 and RO1-DK078112.",

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AU - Greene, Tom

AU - Beddhu, Srinivasan

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N2 - High serum alkaline phosphatase concentrations are associated with elevated serum C-reactive protein (CRP) levels in the general population. To examine whether this association is independent of serum vitamin D levels or modified in chronic kidney disease (CKD), we determined if such associations exist using data from the National Health and Nutrition Examination Survey III of 14,420 adult participants in which 5.7% had CKD (defined as estimated glomerular filtration rate 60 ml/min per 1.73 m2). For each doubling of serum alkaline phosphatase, the odds of elevated serum CRP (over 3 mg/l) were increased 2.73-fold in the non-chronic and 2.50-fold in the CKD sub-populations, respectively. Regression coefficients of each doubling of serum alkaline phosphatase with elevated CRP were not significantly different in between the sub-populations. Additional adjustment for the serum 25-hydroxy (OH) vitamin D level did not substantively change the results. Thus, associations of serum alkaline phosphatase with elevated CRP are independent of serum 25-OH vitamin D in the chronic and non-CKD populations. Hence, serum alkaline phosphatase might be a marker of the inflammatory milieu.

AB - High serum alkaline phosphatase concentrations are associated with elevated serum C-reactive protein (CRP) levels in the general population. To examine whether this association is independent of serum vitamin D levels or modified in chronic kidney disease (CKD), we determined if such associations exist using data from the National Health and Nutrition Examination Survey III of 14,420 adult participants in which 5.7% had CKD (defined as estimated glomerular filtration rate 60 ml/min per 1.73 m2). For each doubling of serum alkaline phosphatase, the odds of elevated serum CRP (over 3 mg/l) were increased 2.73-fold in the non-chronic and 2.50-fold in the CKD sub-populations, respectively. Regression coefficients of each doubling of serum alkaline phosphatase with elevated CRP were not significantly different in between the sub-populations. Additional adjustment for the serum 25-hydroxy (OH) vitamin D level did not substantively change the results. Thus, associations of serum alkaline phosphatase with elevated CRP are independent of serum 25-OH vitamin D in the chronic and non-CKD populations. Hence, serum alkaline phosphatase might be a marker of the inflammatory milieu.

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Serum alkaline phosphatase levels associate with elevated serum C-reactive protein in chronic kidney disease

Abstract

Keywords

ASJC Scopus subject areas

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