Serum bicarbonate and cardiovascular events in hypertensive adults: Results from the Systolic Blood Pressure Intervention Trial

Mirela Dobre, Nicholas M. Pajewski, Srinivasan Beddhu, Michel Chonchol, Thomas H. Hostetter, Ping Li, Mahboob Rahman, Karen Servilla, Daniel E. Weiner, Jackson T. Wright, Kalani L. Raphael

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Background. Low serum bicarbonate level is associated with increased mortality, but its role as a predictor of cardiovascular disease (CVD) is unclear. This study evaluates the association between serum bicarbonate concentration and CVD and whether the effect of intensive blood pressure (BP) lowering on CVD outcomes is modified by serum bicarbonate level. Methods. The Systolic Blood Pressure Intervention Trial (SPRINT) randomized participants to a systolic BP target <120 mmHg (intensive treatment) or <140 mmHg (standard treatment). The primary CVD outcome was a composite of nonfatal myocardial infarction (MI), acute coronary syndrome not resulting in MI, stroke, acute decompensated heart failure and CVD death. Cox proportional hazards models adjusted for demographic, clinical and laboratory characteristics were used to evaluate the association of interest in 9334 SPRINT participants ( NCT01206062). Results. Over a median follow-up of 3.33 years (interquartile range 2.87–3.87 years), 618 (6.6%) participants experienced a primary CVD outcome. Participants with serum bicarbonate <22 mEq/L had a significantly higher risk of the primary CVD outcome (hazard ratio 1.54; 95% confidence interval 1.11–2.14, P ¼ 0.01), compared with participants with bicarbonate 22–26 mEq/L. The magnitude of the CVD risk reduction with intensive BP lowering was similar across bicarbonate strata (P-value for interaction ¼ 0.97). Conclusions. In hypertensive individuals, serum bicarbonate level <22 mEq/L was associated with an increased CVD risk. The effect of intensive BP lowering on CVD outcomes was not modified by the serum bicarbonate level.

Original languageEnglish (US)
Pages (from-to)1377-1384
Number of pages8
JournalNephrology Dialysis Transplantation
Issue number8
StatePublished - Aug 1 2020


  • Cardiovascular disease
  • Mortality
  • Serum bicarbonate

ASJC Scopus subject areas

  • Nephrology
  • Transplantation


Dive into the research topics of 'Serum bicarbonate and cardiovascular events in hypertensive adults: Results from the Systolic Blood Pressure Intervention Trial'. Together they form a unique fingerprint.

Cite this