Serum Levels of α-Klotho Are Correlated with Cerebrospinal Fluid Levels and Predict Measures of Cognitive Function

Payel Kundu; Benjamin Zimmerman; Joseph F. Quinn; Jeffrey Kaye; Nora Mattek; Shawn K. Westaway; Jacob Raber

doi:10.3233/JAD-215719

Serum Levels of α-Klotho Are Correlated with Cerebrospinal Fluid Levels and Predict Measures of Cognitive Function

Payel Kundu, Benjamin Zimmerman, Joseph F. Quinn, Jeffrey Kaye, Nora Mattek, Shawn K. Westaway, Jacob Raber

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: α-klotho might play a role in neurodegenerative diseases. Objective: To determine levels of α-klotho and apoE in serum and cerebrospinal fluid (CSF) samples and their relationship with the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating (CDR). Methods: All subjects were between age 39 to 83+ (n = 94). CDR and MMSE were administered to all participants. CSF was collected in the early afternoon by lumbar puncture. Results: Serum and CSF levels of α-klotho are positively correlated and both predict scores on the MMSE and CDR, regardless of sex or apoE4 status. Conclusion: Our results demonstrate that α-klotho may be an important biomarker of cognitive health and neurodegeneration, and that relatively non-invasive sampling of α-klotho from serum is likely highly reflective of CSF levels.

Original language	English (US)
Pages (from-to)	1471-1481
Number of pages	11
Journal	Journal of Alzheimer's Disease
Volume	86
Issue number	3
DOIs	https://doi.org/10.3233/JAD-215719
State	Published - 2022

Keywords

Clinical Dementia Rating
Mini-Mental State Examination
apoE
cerebrospinal fluid
serum
α-klotho

ASJC Scopus subject areas

Neuroscience(all)
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

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10.3233/JAD-215719

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@article{2e7957dfed1a4f4db5ee82cd80455166,

title = "Serum Levels of α-Klotho Are Correlated with Cerebrospinal Fluid Levels and Predict Measures of Cognitive Function",

abstract = "Background: α-klotho might play a role in neurodegenerative diseases. Objective: To determine levels of α-klotho and apoE in serum and cerebrospinal fluid (CSF) samples and their relationship with the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating (CDR). Methods: All subjects were between age 39 to 83+ (n = 94). CDR and MMSE were administered to all participants. CSF was collected in the early afternoon by lumbar puncture. Results: Serum and CSF levels of α-klotho are positively correlated and both predict scores on the MMSE and CDR, regardless of sex or apoE4 status. Conclusion: Our results demonstrate that α-klotho may be an important biomarker of cognitive health and neurodegeneration, and that relatively non-invasive sampling of α-klotho from serum is likely highly reflective of CSF levels.",

keywords = "Clinical Dementia Rating, Mini-Mental State Examination, apoE, cerebrospinal fluid, serum, α-klotho",

author = "Payel Kundu and Benjamin Zimmerman and Quinn, {Joseph F.} and Jeffrey Kaye and Nora Mattek and Westaway, {Shawn K.} and Jacob Raber",

note = "Funding Information: The current study was partially supported by NIA T32 AG055378 (PK), a Beckman Postdoctoral Fellowship with funding provided by the Arnold and Mabel Beckman Foundation, and a Burroughs Welcome Fund Collaborative Research Travel Grant (1018797) (BZ), NIH RF1 AG059088, R21 AG065914 (JR), and a grant to the OHSU Alzheimer{\textquoteright}s Disease Research Center (NIH P30-AG066518; P30-AG008017) (JK). Publisher Copyright: {\textcopyright} 2022 - The authors. Published by IOS Press.",

year = "2022",

doi = "10.3233/JAD-215719",

language = "English (US)",

volume = "86",

pages = "1471--1481",

journal = "Journal of Alzheimer's Disease",

issn = "1387-2877",

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TY - JOUR

T1 - Serum Levels of α-Klotho Are Correlated with Cerebrospinal Fluid Levels and Predict Measures of Cognitive Function

AU - Kundu, Payel

AU - Zimmerman, Benjamin

AU - Quinn, Joseph F.

AU - Kaye, Jeffrey

AU - Mattek, Nora

AU - Westaway, Shawn K.

AU - Raber, Jacob

N1 - Funding Information: The current study was partially supported by NIA T32 AG055378 (PK), a Beckman Postdoctoral Fellowship with funding provided by the Arnold and Mabel Beckman Foundation, and a Burroughs Welcome Fund Collaborative Research Travel Grant (1018797) (BZ), NIH RF1 AG059088, R21 AG065914 (JR), and a grant to the OHSU Alzheimer’s Disease Research Center (NIH P30-AG066518; P30-AG008017) (JK). Publisher Copyright: © 2022 - The authors. Published by IOS Press.

PY - 2022

Y1 - 2022

N2 - Background: α-klotho might play a role in neurodegenerative diseases. Objective: To determine levels of α-klotho and apoE in serum and cerebrospinal fluid (CSF) samples and their relationship with the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating (CDR). Methods: All subjects were between age 39 to 83+ (n = 94). CDR and MMSE were administered to all participants. CSF was collected in the early afternoon by lumbar puncture. Results: Serum and CSF levels of α-klotho are positively correlated and both predict scores on the MMSE and CDR, regardless of sex or apoE4 status. Conclusion: Our results demonstrate that α-klotho may be an important biomarker of cognitive health and neurodegeneration, and that relatively non-invasive sampling of α-klotho from serum is likely highly reflective of CSF levels.

AB - Background: α-klotho might play a role in neurodegenerative diseases. Objective: To determine levels of α-klotho and apoE in serum and cerebrospinal fluid (CSF) samples and their relationship with the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating (CDR). Methods: All subjects were between age 39 to 83+ (n = 94). CDR and MMSE were administered to all participants. CSF was collected in the early afternoon by lumbar puncture. Results: Serum and CSF levels of α-klotho are positively correlated and both predict scores on the MMSE and CDR, regardless of sex or apoE4 status. Conclusion: Our results demonstrate that α-klotho may be an important biomarker of cognitive health and neurodegeneration, and that relatively non-invasive sampling of α-klotho from serum is likely highly reflective of CSF levels.

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Serum Levels of α-Klotho Are Correlated with Cerebrospinal Fluid Levels and Predict Measures of Cognitive Function

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