TY - JOUR
T1 - Severity of demyelination in vivo correlates with serum myelination inhibition activity in guinea pigs having a new form of experimental allergic encephalomyelitis
AU - Bourdette, Dennis N.
AU - Driscoll, Bernard F.
AU - Seil, Fredrick J.
AU - Kies, Marian W.
AU - Alvord, Ellsworth C.
PY - 1986/2
Y1 - 1986/2
N2 - Guinea pigs received a suboptimal transfer of lymphocytes sensitized to myelin basic protein (BP) and were then immunized with guinea pig BP, BP plus chicken brain or chicken myelin, or chicken brain alone. Sera from these animals were tested for the presence of myelinotoxic antibodies, as detected by the myelination inhibition assay. Myelination inhibition activity correlated with the histologic severity of demyelination.
AB - Guinea pigs received a suboptimal transfer of lymphocytes sensitized to myelin basic protein (BP) and were then immunized with guinea pig BP, BP plus chicken brain or chicken myelin, or chicken brain alone. Sera from these animals were tested for the presence of myelinotoxic antibodies, as detected by the myelination inhibition assay. Myelination inhibition activity correlated with the histologic severity of demyelination.
KW - Experimental allergic encephalomyelitis
KW - antibody-mediated demyelination
KW - demyelinating diseases
KW - mechanisms of demyelination
KW - myelination inhibition in vitro
KW - myelinotoxic antibodies
UR - http://www.scopus.com/inward/record.url?scp=0022666475&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022666475&partnerID=8YFLogxK
U2 - 10.1007/BF02834294
DO - 10.1007/BF02834294
M3 - Article
C2 - 2423931
AN - SCOPUS:0022666475
SN - 0734-600X
VL - 4
SP - 1
EP - 9
JO - Neurochemical Pathology
JF - Neurochemical Pathology
IS - 1
ER -