Abstract
Guinea pigs received a suboptimal transfer of lymphocytes sensitized to myelin basic protein (BP) and were then immunized with guinea pig BP, BP plus chicken brain or chicken myelin, or chicken brain alone. Sera from these animals were tested for the presence of myelinotoxic antibodies, as detected by the myelination inhibition assay. Myelination inhibition activity correlated with the histologic severity of demyelination.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | Neurochemical Pathology |
| Volume | 4 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1986 |
Keywords
- Experimental allergic encephalomyelitis
- antibody-mediated demyelination
- demyelinating diseases
- mechanisms of demyelination
- myelination inhibition in vitro
- myelinotoxic antibodies
ASJC Scopus subject areas
- Molecular Biology
- Clinical Neurology
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