TY - JOUR
T1 - Sex-specific patterns of white matter microstructure are associated with emerging depression during adolescence
AU - Kliamovich, Dakota
AU - Jones, Scott A.
AU - Chiapuzio, Alexandra M.
AU - Baker, Fiona C.
AU - Clark, Duncan B.
AU - Nagel, Bonnie J.
N1 - Funding Information:
The authors would like to extend special thanks to Angelica M. Morales, Ph.D. (Department of Psychiatry, Oregon Health & Science University, Portland, OR) for her invaluable assistance with DTI analyses. Past and current members of the Developmental Brain Imaging Laboratory are also thanked for their help with participant scheduling and data collection. This work was supported by the ARCS Foundation [Kliamovich], as well as the U.S. National Institute on Alcohol Abuse and Alcoholism [Kliamovich: T32AA007468] with co-funding from the National Institute on Drug Abuse, the National Institute of Mental Health, and the National Institute of Child Health and Human Development , [NCANDA grant numbers: AA021697, AA021695, AA021692, AA021696, AA021681, AA021690, AA021691 ]. Additional support was provided by the National Institutes of Health [S10OD021701 and S10OD018224] for the 3T Siemens Prisma MRI instrument and High-Performance Computing Cluster, housed in OHSU's Advanced Imaging Research Center, and supported by the Oregon Opportunity Partnership for advancing biomedical research.
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/9/30
Y1 - 2021/9/30
N2 - Prior research has demonstrated associations between adolescent depression and alterations in the white matter microstructure of fiber tracts implicated in emotion regulation. Using diffusion tensor imaging, this study explored premorbid, sex-specific white matter microstructural features that related to future emergence of major depressive disorder (MDD) during adolescence and young adulthood. Adolescents from the National Consortium on Alcohol and Neurodevelopment in Adolescence study, who were 12–21 years old at study entry and had not experienced major depression as of the baseline assessment, were selected for inclusion (N = 462, n = 223 female adolescents). Over five years of annual follow-up, 63 participants developed a diagnosis of MDD, as determined by the Computerized Semi-Structured Assessment for the Genetics of Alcoholism (n = 39 female adolescents). A whole-brain multivariate modeling approach was used to examine the relationship between fractional anisotropy (FA) at baseline and emergence into MDD, as a function of sex, controlling for age at baseline. Among female adolescents, those who developed MDD had significantly lower baseline FA in a portion of left precentral gyrus white matter, while male adolescents exhibited the opposite pattern. These results may serve as indirect microstructural markers of risk and targets for the prevention of depression during adolescence.
AB - Prior research has demonstrated associations between adolescent depression and alterations in the white matter microstructure of fiber tracts implicated in emotion regulation. Using diffusion tensor imaging, this study explored premorbid, sex-specific white matter microstructural features that related to future emergence of major depressive disorder (MDD) during adolescence and young adulthood. Adolescents from the National Consortium on Alcohol and Neurodevelopment in Adolescence study, who were 12–21 years old at study entry and had not experienced major depression as of the baseline assessment, were selected for inclusion (N = 462, n = 223 female adolescents). Over five years of annual follow-up, 63 participants developed a diagnosis of MDD, as determined by the Computerized Semi-Structured Assessment for the Genetics of Alcoholism (n = 39 female adolescents). A whole-brain multivariate modeling approach was used to examine the relationship between fractional anisotropy (FA) at baseline and emergence into MDD, as a function of sex, controlling for age at baseline. Among female adolescents, those who developed MDD had significantly lower baseline FA in a portion of left precentral gyrus white matter, while male adolescents exhibited the opposite pattern. These results may serve as indirect microstructural markers of risk and targets for the prevention of depression during adolescence.
KW - Diffusion tensor imaging
KW - Major depressive disorder
KW - Sex differences
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U2 - 10.1016/j.pscychresns.2021.111324
DO - 10.1016/j.pscychresns.2021.111324
M3 - Article
C2 - 34273656
AN - SCOPUS:85109893209
SN - 0925-4927
VL - 315
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
M1 - 111324
ER -