Sex steroids, periodontal health, and tooth loss in older men

E. S. Orwoll, B. K.S. Chan, L. C. Lambert, L. M. Marshall, C. Lewis, K. R. Phipps

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Sex steroids have a significant effect on skeletal biology in men, with reduced levels being associated with lower skeletal bone mass and cortical thickness. The purpose of this study was to determine if sex steroids are associated with periodontitis and tooth loss in a cohort of 1210 older dentate men followed for 3 years. Periodontal measures included attachment loss, pocket depth, gingival bleeding, and number of teeth. Baseline serum testosterone and estradiol were measured by radio-immunoassay. Severe periodontitis was common at baseline (38%), and progression occurred in 32% of the cohort. Incident tooth loss occurred in 22% of the cohort. Testosterone, estradiol, and sex hormone binding globulin (SHBG) concentrations were not related to baseline periodontal status or number of teeth. Moreover, there was no relationship between sex steroid levels and periodontitis progression or incident tooth loss. Although periodontitis, progression of periodontitis, and tooth loss are common in older men, they were not associated with sex steroids.

Original languageEnglish (US)
Pages (from-to)704-708
Number of pages5
JournalJournal of dental research
Issue number8
StatePublished - Aug 2009


  • Estradiol
  • Men
  • Periodontitis
  • Testosterone

ASJC Scopus subject areas

  • General Dentistry


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