Sickle Cell Disease: A Brief Update

Sharl Azar, Trisha E. Wong

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations


Sickle cell disease (SCD) is an inherited monogenic disease characterized by misshapen red blood cells that causes vaso-occlusive disease, vasculopathy, and systemic inflammation. Approximately 300,000 infants are born per year with SCD globally. Acute, chronic, and acute-on-chronic complications contribute to end-organ damage and adversely affect quantity and quality of life. Hematopoietic stem cell transplantation is the only cure available today, but is not feasible for the vast majority of people suffering from SCD. Fortunately, new therapies are in late clinical trials and more are in the pipeline, offering hope for this unfortunate disease, which has increasing global burden.

Original languageEnglish (US)
Pages (from-to)375-393
Number of pages19
JournalMedical Clinics of North America
Issue number2
StatePublished - Mar 1 2017


  • Hemoglobinopathy
  • Hydroxyurea
  • Iron overload
  • Review
  • Sickle cell anemia
  • Sickle cell disease

ASJC Scopus subject areas

  • General Medicine


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