Signal transduction and growth control in yeast

Janet Schultz, Betsy Ferguson, George F. Sprague

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


An understanding of how an extracellular stimulus causes changes in cell growth is emerging from the study of four signal transduction pathways in Saccharomyces cerevisiae: the pheromone-response, pseudohyphal differentiation, osmolarity-response, and protein kinase C activated pathways. Each of these pathways contains at its core a distinct mitogen-activated protein kinase cascade. Biochemical and molecular studies have determined the functional order of the kinases in the pheromone-response pathway and have suggested that they are organized into a complex by a protein scaffold. The cell surface sensor system for the osmolarity-response pathway has been identified. It shows striking similarity to bacterial two-component sensor-responder systems. Finally, components that integrate information from these pathways and communicate it to cell growth regulators have been revealed.

Original languageEnglish (US)
Pages (from-to)31-37
Number of pages7
JournalCurrent Opinion in Genetics and Development
Issue number1
StatePublished - Feb 1995

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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