TY - JOUR
T1 - Signaling pathways for PC12 cell differentiation
T2 - Making the right connections
AU - Vaudry, D.
AU - Stork, P. J.S.
AU - Lazarovici, P.
AU - Eiden, L. E.
PY - 2002/5/31
Y1 - 2002/5/31
N2 - A key issue in signal transduction is how signaling pathways common to many systems-so-called canonical signaling cassettes - integrate signals from molecules having a wide spectrum of activities, such as hormones and neurotrophins, to deliver distinct biological outcomes. The neuroendocrine cell line PC12, derived from rat pheochromocytoma, provides an example of how one canonical signaling cassette - the Raf → mitogen-activated protein kinase kinase (MEK) → extracellular signal-regulated kinase (ERK) pathway - can promote distinct outcomes, which in this case include neuritogenesis, gene induction, and proliferation. Two growth hormones, epidermal growth factor (EGF) and nerve growth factor (NGF), use the same pathway to cause PC12 proliferation and differentiation, respectively. In addition, pituitary adenylate cyclase-activating polypeptide (PACAP), a neurotransmitter that also causes differentiation, uses the same canonical cassette as NGF but in a different way. The Connections Map for PC12 Cell Differentiation brings into focus the complex array of specific cellular responses that rely on canonical signal transduction systems.
AB - A key issue in signal transduction is how signaling pathways common to many systems-so-called canonical signaling cassettes - integrate signals from molecules having a wide spectrum of activities, such as hormones and neurotrophins, to deliver distinct biological outcomes. The neuroendocrine cell line PC12, derived from rat pheochromocytoma, provides an example of how one canonical signaling cassette - the Raf → mitogen-activated protein kinase kinase (MEK) → extracellular signal-regulated kinase (ERK) pathway - can promote distinct outcomes, which in this case include neuritogenesis, gene induction, and proliferation. Two growth hormones, epidermal growth factor (EGF) and nerve growth factor (NGF), use the same pathway to cause PC12 proliferation and differentiation, respectively. In addition, pituitary adenylate cyclase-activating polypeptide (PACAP), a neurotransmitter that also causes differentiation, uses the same canonical cassette as NGF but in a different way. The Connections Map for PC12 Cell Differentiation brings into focus the complex array of specific cellular responses that rely on canonical signal transduction systems.
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U2 - 10.1126/science.1071552
DO - 10.1126/science.1071552
M3 - Short survey
C2 - 12040181
AN - SCOPUS:0037205044
SN - 0036-8075
VL - 296
SP - 1648
EP - 1649
JO - Science
JF - Science
IS - 5573
ER -