Significant understaging is seen in clinically staged T2N0 esophageal cancer patients undergoing esophagectomy

James Dolan, T. Kaur, B. S. Diggs, R. A. Luna, B. C. Sheppard, P. H. Schipper, Brandon Tieu, Gennadiy Bakis, Gina Vaccaro, John Holland, K. M. Gatter, M. A. Conroy, C. A. Thomas, J. G. Hunter

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


This study aimed to determine the impact of preoperative staging on the treatment of clinical T2N0 (cT2N0) esophageal cancer patients undergoing esophagectomy. We reviewed a retrospective cohort of 27 patients treated at a single institution between 1999 and 2011. Clinical staging was performed with computed tomography, positron emission tomography, and endoscopic ultrasound. Patients were separated into two groups: neoadjuvant therapy followed by surgery (NEOSURG) and surgery alone (SURG). There were 11 patients (41%) in the NEOSURG group and 16 patients (59%) in the SURG group. In the NEOSURG group, three of 11 patients (27%) had a pathological complete response and eight (73%) were partial or nonresponders after neoadjuvant therapy. In the SURG group, nine of 16 patients (56%) were understaged, 6 (38%) were overstaged, and 1 (6%) was correctly staged. In the entire cohort, despite being clinically node negative, 14 of 27 patients (52%) had node-positive disease (5/11 [45%] in the NEOSURG group, and 9/16 [56%] in the SURG group). Overall survival rate was not statistically significant between the two groups (P = 0.96). Many cT2N0 patients are clinically understaged and show no preoperative evidence of node-positive disease. Consequently, neoadjuvant therapy may have a beneficial role in treatment.

Original languageEnglish (US)
Pages (from-to)320-325
Number of pages6
JournalDiseases of the Esophagus
Issue number4
StatePublished - May 1 2016


  • Chemotherapy
  • Esophageal cancer
  • Esophagectomy
  • Neoadjuvant therapy
  • Oesophageal cancer
  • Radiation therapy

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Significant understaging is seen in clinically staged T2N0 esophageal cancer patients undergoing esophagectomy'. Together they form a unique fingerprint.

Cite this