Silencing the Cochlear Amplifier by Immobilizing Prestin

Ulrich Müller; Peter Gillespie

doi:10.1016/j.neuron.2008.04.018

Silencing the Cochlear Amplifier by Immobilizing Prestin

Ulrich Müller
, Peter Gillespie

Otolaryngology

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

Achieving the exquisite sensitivity and frequency selectivity of the mammalian ear requires active amplification of input sound. In this issue of Neuron, Dallos and colleagues demonstrate that the molecular motor prestin, which drives shape changes in the soma of mechanosensory hair cells, underlies mechanical feedback mechanisms for sound amplification in mammals.

Original language	English (US)
Pages (from-to)	299-301
Number of pages	3
Journal	Neuron
Volume	58
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2008.04.018
State	Published - May 8 2008

Funding

Funders

Funder number

National Institute on Deafness and Other Communication Disorders R01DC012546 Xue Zhong Liu National Institute on Deafness and Other Communication Disorders R01DC012115 Xue Zhong Liu National Institute on Deafness and Other Communication Disorders R01DC014427 Ulrich Müller Peter G Barr-Gillespie National Institute on Deafnessand Other Communication Disorders R01DC005965 Ulrich Müller National Institute on Deafness and Other Communication Disorders

R01DC005965

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2008.04.018

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abstract = "Achieving the exquisite sensitivity and frequency selectivity of the mammalian ear requires active amplification of input sound. In this issue of Neuron, Dallos and colleagues demonstrate that the molecular motor prestin, which drives shape changes in the soma of mechanosensory hair cells, underlies mechanical feedback mechanisms for sound amplification in mammals.",

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AB - Achieving the exquisite sensitivity and frequency selectivity of the mammalian ear requires active amplification of input sound. In this issue of Neuron, Dallos and colleagues demonstrate that the molecular motor prestin, which drives shape changes in the soma of mechanosensory hair cells, underlies mechanical feedback mechanisms for sound amplification in mammals.

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Silencing the Cochlear Amplifier by Immobilizing Prestin

Abstract

Funding

ASJC Scopus subject areas

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