Simple induction and assessment of barbiturate physical dependence in the rat

Richard Letz; J. K. Belknap

doi:10.3758/BF03337516

Simple induction and assessment of barbiturate physical dependence in the rat

Richard Letz, J. K. Belknap

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Physical dependence to phenobarbital via an oral ingestion method was demonstrated in rats. Also, the utility of air-puff-elicited startle for assessing both intoxication and withdrawal effects was shown. Avoidance of phenobarbital-adulterated food was enhanced as a result of prior exposure to chronic phenobarbital intoxication and subsequent withdrawal.

Original language	English (US)
Pages (from-to)	249-252
Number of pages	4
Journal	Physiological Psychology
Volume	3
Issue number	3
DOIs	https://doi.org/10.3758/BF03337516
State	Published - Sep 1975
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)
Physiology

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10.3758/BF03337516

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title = "Simple induction and assessment of barbiturate physical dependence in the rat",

abstract = "Physical dependence to phenobarbital via an oral ingestion method was demonstrated in rats. Also, the utility of air-puff-elicited startle for assessing both intoxication and withdrawal effects was shown. Avoidance of phenobarbital-adulterated food was enhanced as a result of prior exposure to chronic phenobarbital intoxication and subsequent withdrawal.",

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year = "1975",

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journal = "Physiological Psychology",

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AU - Letz, Richard

AU - Belknap, J. K.

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AB - Physical dependence to phenobarbital via an oral ingestion method was demonstrated in rats. Also, the utility of air-puff-elicited startle for assessing both intoxication and withdrawal effects was shown. Avoidance of phenobarbital-adulterated food was enhanced as a result of prior exposure to chronic phenobarbital intoxication and subsequent withdrawal.

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JF - Physiological Psychology

IS - 3

ER -

Simple induction and assessment of barbiturate physical dependence in the rat

Abstract

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