Six-year results of a randomized, prospective trial of human growth hormone and oxandrolone in Turner syndrome

Ron G. Rosenfeld, James France, Kenneth M. Attie, Jo Anne Brasel, Stephen Burstein, Jose F. Cara, Steven Chernausek, Ronald W. Gotlin, Joyce Kuntze, Barbara M. Lippe, Patrick C. Mahoney, Wayne V. Moore, Paul Saenger, Ann J. Johanson

Research output: Contribution to journalArticlepeer-review

170 Scopus citations


Seventy girls with Turner syndrome, verified by karyotype, were randomly assigned to observation or treatment with human growth hormone (hGH), oxandrolone, or a combination of hGH plus oxandrolone for a period of 12 to 24 months, to assess the effect of treatment on growth velocity and adult height. Subsequently, all subjects received either hGH alone or hGH plus oxandrolone. Data are presented for 62 subjects treated for a period of 3 to 6 years. When compared with the anticipated growth rate in untreated patients, the growth rate after treatment with hGH, both alone and in combination with oxandrolone, showed a sustained increase for at least 6 years. Treatment is continuing in over half of the subjects; at present, 14 (82%) of 17 girls receiving hGH alone and 41 (91%) of 45 girls receiving combination therapy exceeded their expected adult heights. Thirty girls have completed treatment; mean height for these 30 patients is 151.9 cm, compared with their mean original projected adult height of 143.8 cm. We conclude that therapy with hGH, alone and in combination with oxandrolone, can result in a sustained increase in growth rate and a significant increase in adult height for most prepubertal girls with Turner syndrome.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalThe Journal of pediatrics
Issue number1
StatePublished - Jul 1992
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Six-year results of a randomized, prospective trial of human growth hormone and oxandrolone in Turner syndrome'. Together they form a unique fingerprint.

Cite this