TY - JOUR
T1 - Smoking before pregnancy and risk of gestational hypertension and preeclampsia
AU - England, Lucinda J.
AU - Levine, Richard J.
AU - Qian, Cong
AU - Morris, Cynthia D.
AU - Sibai, Baha M.
AU - Catalano, Patrick M.
AU - Curet, Luis B.
AU - Klebanoff, Mark A.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2002/5
Y1 - 2002/5
N2 - OBJECTIVE: Our purpose was to determine whether smoking before pregnancy reduces the risk of gestational hypertension or preeclampsia. STUDY DESIGN: The trial of Calcium for Preeclampsia Prevention (CPEP) was a randomized study of 4589 nulliparous women conducted in 5 US medical centers during the years 1992 through 1995. Women were classified into 4 exposure groups by smoking history obtained at study enrollment (13-21 weeks' gestation): (1) never smoked, (2) smoked but quit before the last menstrual period (LMP), (3) smoked but quit after LMP but before enrollment, and (4) smoked and still smoking at enrollment. RESULTS: After adjustments were made for maternal age, race, body mass index, type of health insurance, and clinical center, women smoking at enrollment had a reduced risk of hypertension (relative risk = 0.8; 95% CI, 0.6-0.9). Women who quit smoking before the LMP did not have reduced risk (relative risk = 1.1; 95% CI, 0.9-1.3). Results were similar for gestational hypertension and preeclampsia examined separately. CONCLUSION: Women who smoke but quit before becoming pregnant do not have a reduced risk for gestational hypertension or preeclampsia.
AB - OBJECTIVE: Our purpose was to determine whether smoking before pregnancy reduces the risk of gestational hypertension or preeclampsia. STUDY DESIGN: The trial of Calcium for Preeclampsia Prevention (CPEP) was a randomized study of 4589 nulliparous women conducted in 5 US medical centers during the years 1992 through 1995. Women were classified into 4 exposure groups by smoking history obtained at study enrollment (13-21 weeks' gestation): (1) never smoked, (2) smoked but quit before the last menstrual period (LMP), (3) smoked but quit after LMP but before enrollment, and (4) smoked and still smoking at enrollment. RESULTS: After adjustments were made for maternal age, race, body mass index, type of health insurance, and clinical center, women smoking at enrollment had a reduced risk of hypertension (relative risk = 0.8; 95% CI, 0.6-0.9). Women who quit smoking before the LMP did not have reduced risk (relative risk = 1.1; 95% CI, 0.9-1.3). Results were similar for gestational hypertension and preeclampsia examined separately. CONCLUSION: Women who smoke but quit before becoming pregnant do not have a reduced risk for gestational hypertension or preeclampsia.
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U2 - 10.1067/mob.2002.122404
DO - 10.1067/mob.2002.122404
M3 - Article
C2 - 12015533
AN - SCOPUS:0036584452
SN - 0002-9378
VL - 186
SP - 1035
EP - 1040
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 5
ER -