Smoking before pregnancy and risk of gestational hypertension and preeclampsia

Lucinda J. England, Richard J. Levine, Cong Qian, Cynthia D. Morris, Baha M. Sibai, Patrick M. Catalano, Luis B. Curet, Mark A. Klebanoff

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


OBJECTIVE: Our purpose was to determine whether smoking before pregnancy reduces the risk of gestational hypertension or preeclampsia. STUDY DESIGN: The trial of Calcium for Preeclampsia Prevention (CPEP) was a randomized study of 4589 nulliparous women conducted in 5 US medical centers during the years 1992 through 1995. Women were classified into 4 exposure groups by smoking history obtained at study enrollment (13-21 weeks' gestation): (1) never smoked, (2) smoked but quit before the last menstrual period (LMP), (3) smoked but quit after LMP but before enrollment, and (4) smoked and still smoking at enrollment. RESULTS: After adjustments were made for maternal age, race, body mass index, type of health insurance, and clinical center, women smoking at enrollment had a reduced risk of hypertension (relative risk = 0.8; 95% CI, 0.6-0.9). Women who quit smoking before the LMP did not have reduced risk (relative risk = 1.1; 95% CI, 0.9-1.3). Results were similar for gestational hypertension and preeclampsia examined separately. CONCLUSION: Women who smoke but quit before becoming pregnant do not have a reduced risk for gestational hypertension or preeclampsia.

Original languageEnglish (US)
Pages (from-to)1035-1040
Number of pages6
JournalAmerican journal of obstetrics and gynecology
Issue number5
StatePublished - May 2002

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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