Sodium valproate in tardive dyskinesia

D. E. Casey, J. P. Hammerstad

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Recent findings suggest that tardive dyskinesia may involve GABA-ergic influences in addition to dopaminergic receptor hypersensitivity and relative cholinergic hypofunction. Sodium valproate, which may increase brain GABA, moderately reduced tardive dyskinesia with doses of 900-3000 mg/day, as measured by a tremor-graph and rating scales. There was no correlation between dosage, blood levels, or clinical response. Although the symptoms were not completely controlled, valproate and other GABA-ergic agents may be useful compounds in studying and treating tardive dyskinesia.

Original languageEnglish (US)
Pages (from-to)483-485
Number of pages3
JournalJournal of Clinical Psychiatry
Issue number11
StatePublished - Dec 1 1979

ASJC Scopus subject areas

  • Psychiatry and Mental health


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