Abstract
Recent findings suggest that tardive dyskinesia may involve GABA-ergic influences in addition to dopaminergic receptor hypersensitivity and relative cholinergic hypofunction. Sodium valproate, which may increase brain GABA, moderately reduced tardive dyskinesia with doses of 900-3000 mg/day, as measured by a tremor-graph and rating scales. There was no correlation between dosage, blood levels, or clinical response. Although the symptoms were not completely controlled, valproate and other GABA-ergic agents may be useful compounds in studying and treating tardive dyskinesia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 483-485 |
| Number of pages | 3 |
| Journal | Journal of Clinical Psychiatry |
| Volume | 40 |
| Issue number | 11 |
| State | Published - Dec 1 1979 |
ASJC Scopus subject areas
- Psychiatry and Mental health