Sonothrombolysis: An Emerging Modality for the Treatment of Acute Ischemic and Hemorrhagic Stroke

Azita Soltani, Wayne M. Clark, Douglas R. Hansmann

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


To date, it is believed that rapid removal of impedances hindering normal blood circulation in the brain would salvage ischemic tissue. Hence, most treatment modalities undergoing clinical evaluation for treatment of stroke are focused on faster recanalization in acute ischemic stroke or faster hematoma mass reduction in hemorrhagic stroke. Therapeutic ultrasound is among the promising emerging modalities being clinically evaluated to meet this purpose. This review provides an overview of existing clinical data in evaluating sonothrombolysis applications in treatment of acute ischemic and hemorrhagic stroke. Furthermore, the present status of clinical evaluation of microbubbles as a potential adjuvant to this modality is reviewed.

Original languageEnglish (US)
Pages (from-to)159-170
Number of pages12
JournalTranslational Stroke Research
Issue number2
StatePublished - Jun 2011


  • Acute ischemic stroke
  • Endovascular sonothrombolysis
  • Hemorrhagic stroke
  • Transcranial sonothrombolysis

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Sonothrombolysis: An Emerging Modality for the Treatment of Acute Ischemic and Hemorrhagic Stroke'. Together they form a unique fingerprint.

Cite this