TY - JOUR
T1 - Specific pathogen free macaque colonies
T2 - A review of principles and recent advances for viral testing and colony management
AU - Yee, Joann L.
AU - Vanderford, Thomas H.
AU - Didier, Elizabeth S.
AU - Gray, Stanton
AU - Lewis, Anne
AU - Roberts, Jeffrey
AU - Taylor, Kerry
AU - Bohm, Rudolf P.
N1 - Publisher Copyright:
© 2016 John Wiley & Sons A/S.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Specific pathogen free (SPF) macaques provide valuable animal models for biomedical research. In 1989, the National Center for Research Resources [now Office of Research Infrastructure Programs (ORIP)] of the National Institutes of Health initiated experimental research contracts to establish and maintain SPF colonies. The derivation and maintenance of SPF macaque colonies is a complex undertaking requiring knowledge of the biology of the agents for exclusion and normal physiology and behavior of macaques, application of the latest diagnostic technology, facilitiy management, and animal husbandry. This review provides information on the biology of the four viral agents targeted for exclusion in ORIP SPF macaque colonies, describes current state-of-the-art viral diagnostic algorithms, presents data from proficiency testing of diagnostic assays between laboratories at institutions participating in the ORIP SPF program, and outlines management strategies for maintaining the integrity of SPF colonies using results of diagnostic testing as a guide to decision making.
AB - Specific pathogen free (SPF) macaques provide valuable animal models for biomedical research. In 1989, the National Center for Research Resources [now Office of Research Infrastructure Programs (ORIP)] of the National Institutes of Health initiated experimental research contracts to establish and maintain SPF colonies. The derivation and maintenance of SPF macaque colonies is a complex undertaking requiring knowledge of the biology of the agents for exclusion and normal physiology and behavior of macaques, application of the latest diagnostic technology, facilitiy management, and animal husbandry. This review provides information on the biology of the four viral agents targeted for exclusion in ORIP SPF macaque colonies, describes current state-of-the-art viral diagnostic algorithms, presents data from proficiency testing of diagnostic assays between laboratories at institutions participating in the ORIP SPF program, and outlines management strategies for maintaining the integrity of SPF colonies using results of diagnostic testing as a guide to decision making.
KW - Herpes B virus
KW - Macaque colony management
KW - Simian T-cell lymphotropic virus
KW - Simian betaretrovirus
KW - Simian immunodeficiency virus
KW - Specific pathogen free
KW - Virus testing
UR - http://www.scopus.com/inward/record.url?scp=84961262677&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961262677&partnerID=8YFLogxK
U2 - 10.1111/jmp.12209
DO - 10.1111/jmp.12209
M3 - Review article
C2 - 26932456
AN - SCOPUS:84961262677
SN - 0047-2565
VL - 45
SP - 55
EP - 78
JO - Journal of medical primatology
JF - Journal of medical primatology
IS - 2
ER -