TY - JOUR
T1 - Spectral domain optical coherence tomographic imaging of geographic atrophy
AU - Lujan, Brandon J.
AU - Rosenfeld, Philip J.
AU - Gregori, Giovanni
AU - Wang, Fenghua
AU - Knighton, Robert W.
AU - Feuer, William J.
AU - Puliafito, Carmen A.
PY - 2009/3
Y1 - 2009/3
N2 - ■ BACKGROUND AND OBJECTIVE: To compare images of geographic atrophy (GA) obtained using spectral domain optical coherence tomography (SD-OCT) with images obtained using fundus autofluorescence (FAF). ■ PATIENTs AND METHODs: Five eyes from patients with dry AMD were imaged using SD-OCT and FAF, and the size and shape of the GA were compared. ■ RESULTS: GA appears bright on SD-OCT compared with the surrounding areas with an intact retinal pigment epithelium because of increased reflectivity from the underlying choroid. SD-OCT and FAF both identified GA reproducibly, and measurement of the area of GA is comparable between the two methods with a mean difference of 2.7% of the total area. ■ CONCLUSION: SD-OCT can identify and quantitate areas of GA. The size and shape of these areas correlate well to the areas of GA seen on autofluorescence images; however, SD-OCT imaging also provides important cross-sectional anatomic information.
AB - ■ BACKGROUND AND OBJECTIVE: To compare images of geographic atrophy (GA) obtained using spectral domain optical coherence tomography (SD-OCT) with images obtained using fundus autofluorescence (FAF). ■ PATIENTs AND METHODs: Five eyes from patients with dry AMD were imaged using SD-OCT and FAF, and the size and shape of the GA were compared. ■ RESULTS: GA appears bright on SD-OCT compared with the surrounding areas with an intact retinal pigment epithelium because of increased reflectivity from the underlying choroid. SD-OCT and FAF both identified GA reproducibly, and measurement of the area of GA is comparable between the two methods with a mean difference of 2.7% of the total area. ■ CONCLUSION: SD-OCT can identify and quantitate areas of GA. The size and shape of these areas correlate well to the areas of GA seen on autofluorescence images; however, SD-OCT imaging also provides important cross-sectional anatomic information.
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U2 - 10.3928/15428877-20090301-16
DO - 10.3928/15428877-20090301-16
M3 - Article
C2 - 19320296
AN - SCOPUS:64849111960
SN - 1542-8877
VL - 40
SP - 96
EP - 101
JO - Ophthalmic Surgery Lasers and Imaging
JF - Ophthalmic Surgery Lasers and Imaging
IS - 2
ER -