Spectral domain optical coherence tomography findings in eyes with acute ischaemic retinal whitening

Patrick A. Coady, Emmett T. Cunningham, Robin A. Vora, H. Richard McDonald, Robert N. Johnson, J. Michael Jumper, Arthur D. Fu, Sara J. Haug, Steven L. Williams, Brandon J. Lujan

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


Acute retinal ischaemia presents in various forms depending on the type and location of the associated vascular occlusion. Cotton wool spots have been considered one manifestation of ischaemia and represent swelling in the nerve fibre layer. However, clinical retinal whitening also occurs in areas not affected by cotton wool spots, and has distinguishing spectral domain optical coherence tomography (SD-OCT) features. We present SD-OCT findings of hyper-reflectivity and thickening in four eyes with representative retinal arterial or retinal venous occlusions, specifically branch retinal artery occlusion, central retinal vein occlusion, Purtscher-like retinopathy and ophthalmic artery occlusion. The spectrum of retinal ischaemia from various causes was found to manifest in inner nuclear layer hyper-reflectivity and thickening on SD-OCT. En Face OCT imaging further characterises the topographical distribution of ischaemia, and reveals patterns which provide insight into the pathological processes involved.

Original languageEnglish (US)
Pages (from-to)586-592
Number of pages7
JournalBritish Journal of Ophthalmology
Issue number5
StatePublished - May 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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