@article{ababe0df498b4cd293ed61f22d5966b6,
title = "Speech-related auditory salience detection in the posterior superior temporal region",
abstract = "Processing auditory human speech requires both detection (early and transient) and analysis (sustained). We analyzed high gamma (70–110 Hz) activity of intracranial electroencephalography waveforms acquired during an auditory task that paired forward speech, reverse speech, and signal correlated noise. We identified widespread superior temporal sites with sustained activity responding only to forward and reverse speech regardless of paired order. More localized superior temporal auditory onset sites responded to all stimulus types when presented first in a pair and responded in recurrent fashion to the second paired stimulus in select conditions even in the absence of interstimulus silence; a novel finding. Auditory onset activity to a second paired sound recurred according to relative salience, with evidence of partial suppression during linguistic processing. We propose that temporal lobe auditory onset sites facilitate a salience detector function with hysteresis of 200 ms and are influenced by cortico-cortical feedback loops involving linguistic processing and articulation.",
keywords = "Auditory, Language comprehension, Onset, Salience detector, Superior temporal, Wernicke",
author = "Brown, {Erik C.} and Brittany Stedelin and Seiji Koike and Raslan, {Ahmed M.} and Selden, {Nathan R.}",
note = "Funding Information: We acknowledge patients and families for their interest and willingness to participate in this study as they journey on their individual paths toward improved seizure control and quality of life. We very much appreciate the Oregon Health & Science University's Clinical Neurophysiology team of the Department of Neurology for assistance along the way, especially Aaron Kawamoto, Allison Gardner, Cecily Key, Emily Stair, Inrun Kaur, Kevin Vinecore, and the team's Director Ilker Yaylali, MD, PhD. The OHSU Adult and Doernbecher Pediatric Epilepsy Teams were helpful in guiding patients to feel comfortable with the study, especially Jason Coryell, MD, Colin M. Roberts, MD, Carter D. Wray, MD, Ittai Bushlin, MD, PhD, Paul V. Motika, MD, Lia Ernst, MD, and David Spencer, MD. The help and patience of the nursing staff of the Pediatric Intensive Care Unit of Doernbecher Children's hospital as well as the Neurosciences Intensive Care Unit and the Epilepsy Monitoring Unit of OHSU Hospital were critical to data collection and patient comfort. The contribution of David Dunham of OHSU's Clinical Technology Services for providing necessary tools and skills for creation of custom hardware to integrate research audio equipment with clinical EEG acquisition hardware. We thank Shirley McCartney, PhD, for editorial guidance from conception to completion and OHSU Department of Neurological Surgery's research coordinators especially James “Obi” Obayashi and SamanthaYau for IRB regulatory and compliance assistance. The help of the OHSU Biostatistics and Design Program is greatly appreciated for rapidly connecting us to high quality statistics resources to enhance our analysis. Multiple other individuals aided in some form along the way including Paxton Gehling, MD, Karan Rai, Kelly Collins, MD, and others and we are so grateful for their interest and support. Without all the hard-working, helpful people we are surrounded by, we would not be able to see such a project to completion. The first author is forever grateful to Eishi Asano, MD, PhD, of Children's Hospital of Michigan, who has always taken the concept of mentorship to heart and follows through with the idea that it can and should be lifelong. Finally, we thank Reviewer #2 and Reviewer #3 for their inciteful comments and constructive criticisms that helped us to improve this manuscript. The first and corresponding author ECB conceived of, developed, constructed data acquisition devices for, assembled stimulus delivery systems for, performed data acquisition of iEEG signals of, analyzed all patient level electrophysiological signals for, contributed to image processing for, interpreted results of, and constructed the initial draft of this manuscript along with contributing to all stages of editing. The co-author BS assisted with data acquisition, performed image processing especially involving localization and representation of iEEG electrode contact positions in three dimensional space in both individual as well as atlas space, provided insight into results interpretation, and contributed to all stages of editing of this manuscript. The co-author SK provided statistical expertise for the cohort-level analyses and contributed to final interpretation of the data along with final edits to the manuscript. The co-authors AMR and NRS led all integration between clinical and research work, provided insight into results interpretation, and contributed to all stages of editing of this manuscript. All data and related code can be made available, with all protected health information removed, upon reasonable request to the corresponding author. In our supplement, we provide the MATLAB script utilized to generate the signal correlated noise (SCN) stimuli utilized in our study. Also in the supplement, we provide a list of the English word spoken by the first author (ECB) as our forward speech stimuli; the associated sound files can be provided at any time upon reasonable request. Publisher Copyright: {\textcopyright} 2021",
year = "2022",
month = mar,
doi = "10.1016/j.neuroimage.2021.118840",
language = "English (US)",
volume = "248",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
}