TY - JOUR
T1 - Speed of tooth movement is related to stress and IL-1 gene polymorphisms
AU - Iwasaki, Laura R.
AU - Gibson, Colin S.
AU - Crouch, Larry D.
AU - Marx, David B.
AU - Pandey, Janardan P.
AU - Nickel, Jeffrey C.
N1 - Funding Information:
Supported by the American Association of Orthodontists Foundation (Biomedical Research Award) and the UNMC Department of Growth and Development. Based on a thesis submitted to the graduate faculty, UNMC, in partial fulfillment of the requirements for the MS degree of the second author.
PY - 2006/12
Y1 - 2006/12
N2 - Introduction: The variables affecting speed of tooth movement are unquantified. In particular, the effects of stress and human biological variations are unknown. Therefore, our objectives in this study were to determine relationships between (1) stress and velocity of tooth translation (vt), and (2) interleukin-1 (IL-1) gene cluster polymorphisms, IL-1β and IL-1 receptor antagonist (IL-1RA) in gingival crevicular fluid (GCF), and vt. Methods: Ten subjects had their maxillary first premolars extracted and cheek wipe samples genotyped. In each subject, a maxillary canine received 26 kPa and the other received 13 or 52 kPa of stress. GCF samples and tooth movements were measured at 9 or 10 visits over 84 days. Results: Mean vt for canines retracted by 13, 26, and 52 kPa were 0.054, 0.072, and 0.064 mm per day, respectively. Faster vt was shown from 26 kPa than 13 kPa (P = .015) and 52 kPa (P = .030), with higher IL-1β/IL-1RA in GCF at experimental relative to control sites, and in subjects with homozygosity for allele 1 (A1,A1) compared with at least 1 copy of A2 (A2+) at IL-1RN(VNTR86 bp) (P = .032), and with A2+ compared with A1,A1 at IL-1B(+3954) (P = .051). Conclusions: Stress, IL-1β/IL-1RA in GCF, and IL-1 gene cluster polymorphisms are related to vt.
AB - Introduction: The variables affecting speed of tooth movement are unquantified. In particular, the effects of stress and human biological variations are unknown. Therefore, our objectives in this study were to determine relationships between (1) stress and velocity of tooth translation (vt), and (2) interleukin-1 (IL-1) gene cluster polymorphisms, IL-1β and IL-1 receptor antagonist (IL-1RA) in gingival crevicular fluid (GCF), and vt. Methods: Ten subjects had their maxillary first premolars extracted and cheek wipe samples genotyped. In each subject, a maxillary canine received 26 kPa and the other received 13 or 52 kPa of stress. GCF samples and tooth movements were measured at 9 or 10 visits over 84 days. Results: Mean vt for canines retracted by 13, 26, and 52 kPa were 0.054, 0.072, and 0.064 mm per day, respectively. Faster vt was shown from 26 kPa than 13 kPa (P = .015) and 52 kPa (P = .030), with higher IL-1β/IL-1RA in GCF at experimental relative to control sites, and in subjects with homozygosity for allele 1 (A1,A1) compared with at least 1 copy of A2 (A2+) at IL-1RN(VNTR86 bp) (P = .032), and with A2+ compared with A1,A1 at IL-1B(+3954) (P = .051). Conclusions: Stress, IL-1β/IL-1RA in GCF, and IL-1 gene cluster polymorphisms are related to vt.
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U2 - 10.1016/j.ajodo.2006.04.022
DO - 10.1016/j.ajodo.2006.04.022
M3 - Article
C2 - 17169726
AN - SCOPUS:33845339265
SN - 0889-5406
VL - 130
SP - 698.e1-698.e9
JO - American Journal of Orthodontics and Dentofacial Orthopedics
JF - American Journal of Orthodontics and Dentofacial Orthopedics
IS - 6
ER -