Spermatogonial stem cell transplantation to the testis

Shaun Goodyear, Ralph Brinster

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Spermatogonial stem cells (SSCs) are located in the basal region of the seminiferous tubules and provide a self-renewing reservoir from which progenitor spermatogonia arise and transiently amplify in number before transition to a differentiating state. SSC transplantation involves grafting mouse testicular cells into the seminiferous tubules of an aspermic recipient testis that is generated either by chemical (e.g., busulfan) treatment or genetic mutations.

Original languageEnglish (US)
Pages (from-to)299-305
Number of pages7
JournalCold Spring Harbor Protocols
Issue number4
StatePublished - Apr 2017

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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