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Splenic accumulation of interleukin-3-dependent hematopoietic cells in Friend erythroleukemia

  • C. Spiro
  • , B. C. Gliniak
  • , D. Kabat

Research output: Contribution to journalArticlepeer-review

Abstract

Interleukin-3-dependent hematopoietic stem cells commonly accumulate in spleens of mice infected with leukemia viruses. To study their origins, a molecularly tagged helper-free Friend spleen focus-forming virus was used to produce erythroleukemias. Uninfected interleukin-3-dependent basophil-mast cell progenitors coproliferated amidst the spleen focus-forming virus-infected leukemic cells. Splenic proliferation of normal stem cells is apparently a host response to leukemogenesis, and we propose that it may contribute to certain retroviral diseases.

Original languageEnglish (US)
Pages (from-to)4434-4437
Number of pages4
JournalJournal of virology
Volume63
Issue number10
DOIs
StatePublished - 1989
Externally publishedYes

Funding

FundersFunder number
National Institute of Health-National Cancer InstituteR01CA025810

    ASJC Scopus subject areas

    • Microbiology
    • Immunology
    • Insect Science
    • Virology

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