SRC family kinases in cell volume regulation

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60 Scopus citations


SRC family kinases are a group of nine cytoplasmic protein tyrosine kinases essential for many cell functions. Some appear to be ubiquitously expressed, whereas others are highly tissue specific. The ability of members of the SRC family to influence ion - transport has been recognized for several years. Mounting evidence suggests a broad role for SRC family kinases in the cell response to both hypertonic and hypotonic stress, and in the ensuing regulatory volume increase or decrease. In addition, members of this tyrosine kinase family participate in the mechanotrans-duction that accompanies cell membrane deformation. Finally, at least one SRC family member operates in concert with the p38 MAPK to regulate tonicity-dependent gene transcription.

Original languageEnglish (US)
Pages (from-to)C483-C493
JournalAmerican Journal of Physiology - Cell Physiology
Issue number3 57-3
StatePublished - Mar 1 2005


  • Hypertonicity
  • Hypotonicity
  • Ion transport
  • Transient receptor potential
  • Tyrosine kinase

ASJC Scopus subject areas

  • Physiology
  • Cell Biology


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