Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors

Bart C. Jongbloets, Suzanne Lemstra, Roberta Schellino, Mark H. Broekhoven, Jyoti Parkash, Anita J.C.G.M. Hellemons, Tianyi Mao, Paolo Giacobini, Henriette Van Praag, Silvia De Marchis, Geert M.J. Ramakers, R. Jeroen Pasterkamp

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The guidance protein Semaphorin7A (Sema7A) is required for the proper development of the immune and nervous systems. Despite strong expression in the mature brain, the role of Sema7A in the adult remains poorly defined. Here we show that Sema7A utilizes different cell surface receptors to control the proliferation and differentiation of neural progenitors in the adult hippocampal dentate gyrus (DG), one of the select regions of the mature brain where neurogenesis occurs. PlexinC1 is selectively expressed in early neural progenitors in the adult mouse DG and mediates the inhibitory effects of Sema7A on progenitor proliferation. Subsequently, during differentiation of adult-born DG granule cells, Sema7A promotes dendrite growth, complexity and spine development through β1-subunit-containing integrin receptors. Our data identify Sema7A as a key regulator of adult hippocampal neurogenesis, providing an example of how differential receptor usage spatiotemporally controls and diversifies the effects of guidance cues in the adult brain.

Original languageEnglish (US)
Article number14666
JournalNature communications
StatePublished - Mar 10 2017

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)


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