State of the Science in Deceased Organ Donor Management

Madhukar S. Patel; Mitchell Sally; Claus U. Niemann; Darren J. Malinoski

doi:10.1007/s40472-018-0207-8

State of the Science in Deceased Organ Donor Management

Madhukar S. Patel
, Mitchell Sally
, Claus U. Niemann
, Darren J. Malinoski

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Purpose of Review: Research in deceased organ donor management offers an opportunity to increase the quantity and quality of organs available for transplantation. This article aims to appraise the current literature with a focus on reviewing deceased donor intervention trials. Recent Findings: Aggressive critical care management after determination of brain death resulting in meeting of a donor management goal bundle has consistently demonstrated an association with significantly more organs transplanted per donor as well as improved graft outcomes. Although there is a dearth of experience with randomized donor intervention studies, dopamine and targeted mild therapeutic hypothermia have been found to significantly reduce delayed graft function in kidney recipients. Summary: Progress in understanding the ethical, legal, regulatory, policy, and organizational elements of organ donor research has provided a mechanism that allows for the endorsement of potentially impactful donor management studies. Ongoing trials should incorporate methods to ensure safety to all organs donated from donors enrolled in interventional trials.

Original language	English (US)
Pages (from-to)	273-281
Number of pages	9
Journal	Current Transplantation Reports
Volume	5
Issue number	4
DOIs	https://doi.org/10.1007/s40472-018-0207-8
State	Published - Dec 1 2018

Funding

This work was supported in part by the Health Resources and Services Administration contract 234-2005-37011C. The content is the responsibility of the authors alone and does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. Madhukar Patel, Mitchell Sally, and Claus Niemann declare no conflict of interest. Darren Malinoski reports grants from the Laura and John Arnold Foundation, during the conduct of the study.

Funders	Funder number
Health Resources and Services Administration	234-2005-37011C
Laura and John Arnold Foundation

Keywords

Deceased organ donor
Donor intervention research
Organ donor clinical trial
Organ donor management

ASJC Scopus subject areas

Surgery
Immunology
Hepatology
Nephrology
Transplantation

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10.1007/s40472-018-0207-8

Cite this

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title = "State of the Science in Deceased Organ Donor Management",

abstract = "Purpose of Review: Research in deceased organ donor management offers an opportunity to increase the quantity and quality of organs available for transplantation. This article aims to appraise the current literature with a focus on reviewing deceased donor intervention trials. Recent Findings: Aggressive critical care management after determination of brain death resulting in meeting of a donor management goal bundle has consistently demonstrated an association with significantly more organs transplanted per donor as well as improved graft outcomes. Although there is a dearth of experience with randomized donor intervention studies, dopamine and targeted mild therapeutic hypothermia have been found to significantly reduce delayed graft function in kidney recipients. Summary: Progress in understanding the ethical, legal, regulatory, policy, and organizational elements of organ donor research has provided a mechanism that allows for the endorsement of potentially impactful donor management studies. Ongoing trials should incorporate methods to ensure safety to all organs donated from donors enrolled in interventional trials.",

keywords = "Deceased organ donor, Donor intervention research, Organ donor clinical trial, Organ donor management",

author = "Patel, \{Madhukar S.\} and Mitchell Sally and Niemann, \{Claus U.\} and Malinoski, \{Darren J.\}",

note = "Publisher Copyright: {\textcopyright} 2018, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.",

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doi = "10.1007/s40472-018-0207-8",

language = "English (US)",

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AU - Patel, Madhukar S.

AU - Sally, Mitchell

AU - Niemann, Claus U.

AU - Malinoski, Darren J.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Purpose of Review: Research in deceased organ donor management offers an opportunity to increase the quantity and quality of organs available for transplantation. This article aims to appraise the current literature with a focus on reviewing deceased donor intervention trials. Recent Findings: Aggressive critical care management after determination of brain death resulting in meeting of a donor management goal bundle has consistently demonstrated an association with significantly more organs transplanted per donor as well as improved graft outcomes. Although there is a dearth of experience with randomized donor intervention studies, dopamine and targeted mild therapeutic hypothermia have been found to significantly reduce delayed graft function in kidney recipients. Summary: Progress in understanding the ethical, legal, regulatory, policy, and organizational elements of organ donor research has provided a mechanism that allows for the endorsement of potentially impactful donor management studies. Ongoing trials should incorporate methods to ensure safety to all organs donated from donors enrolled in interventional trials.

AB - Purpose of Review: Research in deceased organ donor management offers an opportunity to increase the quantity and quality of organs available for transplantation. This article aims to appraise the current literature with a focus on reviewing deceased donor intervention trials. Recent Findings: Aggressive critical care management after determination of brain death resulting in meeting of a donor management goal bundle has consistently demonstrated an association with significantly more organs transplanted per donor as well as improved graft outcomes. Although there is a dearth of experience with randomized donor intervention studies, dopamine and targeted mild therapeutic hypothermia have been found to significantly reduce delayed graft function in kidney recipients. Summary: Progress in understanding the ethical, legal, regulatory, policy, and organizational elements of organ donor research has provided a mechanism that allows for the endorsement of potentially impactful donor management studies. Ongoing trials should incorporate methods to ensure safety to all organs donated from donors enrolled in interventional trials.

KW - Deceased organ donor

KW - Donor intervention research

KW - Organ donor clinical trial

KW - Organ donor management

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ER -

State of the Science in Deceased Organ Donor Management

Abstract

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Keywords

ASJC Scopus subject areas

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