Status Asthmaticus and Central Herniation: A Case for Multidisciplinary Critical Care

Joelle B. Karlik, Tristan Stani, Stephanie Nonas, Aclan Dogan, Ansgar Brambrink

Research output: Contribution to journalArticlepeer-review


A 24-year-old woman with history of asthma was intubated emergently for acute status asthmaticus triggered by acute respiratory syncytial virus infection and treated with permissive hypercapnia. Her ventilation was complicated by auto-positive end-expiratory pressure and elevated peak airway, plateau, and central venous pressures. On hospital day 2, she was noted to have anisocoria. Imaging showed diffuse cerebral edema with central herniation. Difficult ventilation and hypercapnia directly contributed to her severe cerebral edema. Comanagement between neurologic and medical/pulmonary intensivists enabled the management of the competing treatment requirements for status asthmaticus and cerebral edema. This case highlights the importance of balancing conflicting physiologic needs and collaboration between teams.

Original languageEnglish (US)
Pages (from-to)286-290
Number of pages5
JournalA & A case reports
Issue number11
StatePublished - Jun 1 2017

ASJC Scopus subject areas

  • Medicine(all)


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